Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 9 - Aug 14
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Biotin Mouse Anti-Rat CD4 Antibody (S-R631)Product Specification Host Mouse Antigen CD4 Synonyms T cell surface glycoprotein CD4; T cell surface antigen T4 Leu 3; W3 25 antigen; Cd4 Location Cell membrane Accession P05540 Clone Number S R631 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Rt Positive Sample SD Rat splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability &
Product Specification
| Host | Mouse |
| Antigen | CD4 |
| Synonyms | T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; W3/25 antigen; Cd4 |
| Location | Cell membrane |
| Accession | P05540 |
| Clone Number | S-R631 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Rt |
Background
CD4 is a glycoprotein expressed on the surface of certain immune cells, most notably helper T cells. It is a member of the immunoglobulin superfamily and has four immunoglobulin-like domains (D1 to D4). CD4 acts as a co-receptor with the T-cell receptor (TCR) to recognize antigens displayed by MHC class II molecules on antigen-presenting cells. The D1 domain of CD4 binds to the β2 region of MHC class II, bringing the TCR complex and CD4 into close proximity. This allows the tyrosine kinase Lck, bound to the cytoplasmic tail of CD4, to phosphorylate tyrosine residues on the cytoplasmic domains of CD3, amplifying the signal generated by the TCR. CD4 is also the primary receptor for the human immunodeficiency virus (HIV), and its interaction with the HIV gp120 protein is a key step in viral entry.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy