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Description
Invivo anti-Mouse CD119 Recombinant mAbProduct Specification Host Rat Antigen CD119 Synonyms Interferon gamma receptor 1; IFN gamma receptor 1; IFN gamma R1; Interferon gamma receptor alpha chain (IFN gamma R alpha); Ifngr; Ifngr1 Location Cell membrane Accession P15261 Clone Number S 3783 Antibody Type Rat mAb Isotype Rat IgG2a,k Application FCM, In vitro IFNR neutralization, In vivo IFNR neutralization Reactivity Ms Purification Protein G Concentration 5 mg ml Purity >95%(Determined by
Product Specification
| Host | Rat |
| Antigen | CD119 |
| Synonyms | Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; Interferon gamma receptor alpha-chain (IFN-gamma-R-alpha); Ifngr; Ifngr1 |
| Location | Cell membrane |
| Accession | P15261 |
| Clone Number | S-3783 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG2a,k |
| Application | FCM, In vitro IFNγR neutralization, In vivo IFNγR neutralization |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95%(Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
CD119, also termed IFN-γ receptor 1 (IFNGR1), is a 54 kDa type-II cytokine receptor that forms, together with IFNGR2, the high-affinity heterotetrameric receptor for interferon-γ; upon IFN-γ binding it recruits JAK1 and JAK2 to phosphorylate STAT1, thereby driving transcription of antiviral, antigen-presentation and pro-inflammatory genes that activate macrophages, enhance Th1 responses and enforce host defence against intracellular pathogens, while inherited mutations in CD119 cause Mendelian susceptibility to mycobacterial disease.
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