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Description
Biotin Mouse Anti-Human TCR γ/δ Antibody (S-R637)Product Specification Host Mouse Antigen TCR Synonyms T cell receptor ; TCR; TCR Location Cell membrane Accession P03986 B7Z8K6 Clone Number S R637 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human peripheral blood lymphocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of
Product Specification
| Host | Mouse |
| Antigen | TCR γ/δ |
| Synonyms | T cell receptor γ/δ; γ/δ TCR; TCR-γ/δ |
| Location | Cell membrane |
| Accession | P03986、 B7Z8K6 |
| Clone Number | S-R637 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood lymphocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
The TCR γ/δ protein is a distinctive T-cell receptor (TCR) expressed on the surface of γδ T cells, composed of a γ chain and a δ chain linked by disulfide bonds to form a heterodimer, belonging to the immunoglobulin superfamily. Unlike the conventional αβ TCR, the γδ TCR can directly recognize a broad range of antigens (e.g., phosphorylated metabolites, lipids, stress proteins) without requiring MHC presentation, granting it broader antigen specificity. Its variable (V) region diversity arises from V, (D), and J gene segment rearrangements, though it exhibits less diversity than the αβ TCR. γδ T cells are primarily found in mucosal tissues, skin, and the gut, playing crucial roles in early immune defense, tumor surveillance, and tissue repair. They can rapidly secrete cytokines (e.g., IFN-γ, IL-17) or exert cytotoxic effects, serving as key effector cells bridging innate and adaptive immunity.
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