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Ships within 48 hours · Estimated delivery Jul 21 - Jul 26
For Your Every Summer RSVP, with Code: SUMMER15
Description
BMP2 Recombinant Rabbit mAb (S-2312-45)Product Specification Host Rabbit Antigen BMP2 Synonyms Bone morphogenetic protein 2; BMP 2; Bone morphogenetic protein 2A (BMP 2A); BMP2A Immunogen Synthetic Peptide Location Secreted Accession P12643 Clone Number S 2312 45 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample Caco 2, Saos 2, LNCaP, C2C12, RAW264. 7, mouse lung, C6 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | BMP2 |
| Synonyms | Bone morphogenetic protein 2; BMP-2; Bone morphogenetic protein 2A (BMP-2A); BMP2A |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P12643 |
| Clone Number | S-2312-45 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Caco-2, Saos-2, LNCaP, C2C12, RAW264.7, mouse lung, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
Bone Morphogenetic Protein 2 (BMP2) is a 32 kDa secreted signaling molecule belonging to the transforming growth factor-β superfamily that orchestrates osteogenesis, chondrogenesis, and embryonic patterning through binding to type I and type II serine/threonine kinase receptors, triggering Smad-dependent and Smad-independent pathways; recombinant human BMP2 is FDA-approved as an osteoinductive implant to promote spinal fusion and fracture repair, while dysregulated BMP2 expression is implicated in heterotopic ossification, pulmonary hypertension, and several cancers.
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