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Description
TGFBR3 His Tag Protein, HumanProduct Specification Species Human Synonyms TBRIII, TGF beta receptor type 3 Accession Q03167 1 Amino Acid Sequence Gly21 Val787, with C terminal His Expression System HEK293 Molecular Weight 97 180kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after
Product Specification
| Species | Human |
| Synonyms | TBRIII, TGF-beta receptor type 3 |
| Accession | Q03167-1 |
| Amino Acid Sequence | Gly21-Val787, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 97-180kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Gatza CE, Holtzhausen A, Kirkbride KC, et al. Type III TGF‐β receptor enhances colon cancer cell migration and anchorage‐independent growth. Neoplasia. 2011; 13:758‐770. |
Background
Type III receptor (TGFBR3), also known as beta-glycan, is essential and the most abundant receptor that mediates TGF-β signaling. As a high-affinity co-receptor for TGF-β, upon ligand binding, TGFBR3 facilitates ligand binding of TGFBR2, which phosphorylates and activates TGFBR1 kinase activity. Transforming growth factor beta receptor III (TGFBR3) functions as a binding co‐receptor for various cytokines of the TGF‐β superfamily and is thought to play a role in the pathogenesis of some human cancers. Some reports have suggested that TGFBR3 promotes the growth, migration, invasion and metastasis of colon cancer. In contrast, some evidences indicate that TGFBR3 contributes to reduced angiogenesis, tumour invasion and metastasis, and its expression is decreased or absent in most human cancers including breast, liver, lung, kidney, pancreas and prostate cancers.
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