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Description
TRAF2 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen TRAF2 Synonyms TNF receptor associated factor 2; E3 ubiquitin protein ligase TRAF2; RING type E3 ubiquitin transferase TRAF2; Tumor necrosis factor type 2 receptor associated protein 3; TRAP3 Immunogen Synthetic Peptide Location Cytoplasm Accession Q12933 Antibody Type Polyclonal antibody Isotype IgG Application WB, ICC Reactivity Hu Positive Sample HeLa, HEK 293, 293T, Molt 4 Purification Immunogen Affinity
Product Specification
| Host | Rabbit |
| Antigen | TRAF2 |
| Synonyms | TNF receptor-associated factor 2; E3 ubiquitin-protein ligase TRAF2; RING-type E3 ubiquitin transferase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3; TRAP3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | Q12933 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | HeLa, HEK-293, 293T, Molt-4 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:500 | Hu |
Background
TNF receptor-associated factor 2 (TRAF2) is a multifunctional protein that plays a crucial role in mediating signal transduction from members of the TNF receptor superfamily. It is a 56 kDa trimeric protein, consisting of a globular C-terminal TRAF domain and an extended coiled-coil N-terminal region. TRAF2 acts as both an adaptor protein and an E3 ubiquitin ligase, facilitating the activation of downstream signaling pathways such as the JNK/c-Jun and IKK/NF-κB pathways in response to TNFα stimulation. It directly interacts with TNF receptors and forms complexes with other TRAF proteins, such as TRAF1, to mediate anti-apoptotic signals and inhibit caspase activation. Additionally, TRAF2 is involved in various physiological processes, including cell survival, proliferation, and stress responses, and it has been implicated in cancer progression and immune regulation.
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