SKU: 5636112887

Nrf2 Recombinant Rabbit mAb (S-3183)

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Description

Nrf2 Recombinant Rabbit mAb (S-3183)Product Specification Host Rabbit Antigen Nrf2 Synonyms Nuclear factor erythroid 2 related factor 2; NF E2 related factor 2; NFE2 related factor 2; Nrf 2; Nuclear factor; erythroid derived 2; like 2; NRF2 s; NFE2L2 Location Cytoplasm, Nucleus Accession Q16236 Clone Number S 3183 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid

Product Specification


Host Rabbit
Antigen Nrf2
Synonyms Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; Nrf-2; Nuclear factor; erythroid derived 2; like 2; NRF2 s; NFE2L2
Location Cytoplasm, Nucleus
Accession Q16236
Clone Number S-3183
Antibody Type Recombinant mAb
Isotype IgG
Application WB, ICC
Reactivity Hu
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:2000 Hu
ICC 1:500 Hu

Background

Nrf2 (Nuclear factor erythroid 2-related factor 2) is a critical transcription regulatory protein belonging to the basic leucine zipper (bZIP) family, playing a central role in cellular antioxidant defense and detoxification processes. Under homeostatic conditions, Nrf2 is kept at low levels through ubiquitination and degradation via its binding to Keap1 (Kelch-like ECH-associated protein 1). However, under oxidative stress, electrophilic agents, or inflammatory stimuli, conformational changes in Keap1 lead to Nrf2 release and nuclear translocation. In the nucleus, Nrf2 forms heterodimers with small Maf proteins and binds to the antioxidant response element (ARE), activating the expression of genes encoding antioxidant and phase II detoxifying enzymes, including HO-1 (heme oxygenase-1), NQO1 (NAD(P)H quinone oxidoreductase 1), and glutathione synthetase.This pathway not only neutralizes reactive oxygen species (ROS) and free radicals but also contributes to anti-inflammatory responses, metabolic regulation, and mitochondrial function maintenance. Dysregulation of Nrf2 has been linked to various diseases: overactivation is associated with cancer progression, while impaired Nrf2 activity may accelerate neurodegeneration (e.g., Alzheimer’s disease), cardiovascular disorders, and aging. As a result, Nrf2 has emerged as a key therapeutic target for antioxidant and cytoprotective strategies. Natural compounds (e.g., sulforaphane, curcumin) and synthetic drugs can modulate the Nrf2-Keap1 axis to enhance cellular defense mechanisms.

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SKU: 5636112887

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4.2 ★★★★★
Based on 19 reviews
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Product Reviews
L
Verified Purchase
Lisa B.
Houston, US
★★★★★ 5
OUTSTANDING
Format: Kindle
This was very, very good. The world is vast and characters are complex. There is a good plot with a whole lot going on. This is well written. Good twists and turns and some heart breaking moments. You will love these characters, they have heart and loyalty. I am hoping that there will be several more books. We've yet to see anything from the Sea Court but only a mention of them here and there. The Wood Court was given a quick couple of scenes, and only as far as some warriors, we've yet to enter their court and the Shadow Court, I'm not sure if they will be a force for good or bad, but they definitely will play a much bigger role moving forward. This is primarily the Ice and Air Courts. Told in multiple views, which I loved, it gives you a chance to see things from different eyes. There's alot of political maneuvering and deception. I loved it and will pick up the next book as it becomes available. If you like The Fae and the courts, you should love this. I think the author has mucn in store for us.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 8, 2020
J
Verified Purchase
Jessika
Grantham, US
★★★★★ 4
Definitely worth the read!
Format: Kindle
After taking a deep breath and taking in that wicked twist of an ending, I have finally composed myself. My first thought when I started this book was that I love Reyna's character. I was intrigued by her connection with her familiar and the Ruin that is plaguing her land. It came as no surprise that she took her sister's place in an attempt to protect her. When they reach the Air Court everything slows down. This is where it was iffy for me. First of all, I like multiple POV's in books however 7 is a bit much. It starts to interrupt the story line. I felt like I was finally making progress connecting with one character, then it was switched to another person. I felt they all had necessary or pertinent information but not necessarily were they all POV worthy. The only other thing that annoyed me was that Reyna constantly was " trapped." She would rush off without thinking, only to need rescuing. She is brilliant in a fight, but she really doesn't think through anything. Lorcan is amazing. I know he might be on the "bad" list, but his background is so interesting. Eislyn(Reyna's sister) is really so sweet, but calculating. I enjoyed her and Thane's dialogue. The author did an amazing job with the imagery in this book. Everything was so detailed it was easy to fall into the scene. I love unexpected twists and while part of the ending I expected, I wasn't expecting how it took place. All in all, I found it very entertaining and I am very invested in continuing this series. Favorite quotes: "The truth may be twisted but never false." "Who was she if she was not the enemy of the Air Court? What was her purpose of she no longer has that?" "In a war-torn land, love was always a lie."
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Reviewed in the United States on March 4, 2020
K
Verified Purchase
KAB
Bozeman, US
★★★★★ 5
Great Read!!! Great story!!!
Format: Kindle
The series is long, but Ms. Wolfhart does a fantastic job of weaving this tale while bringing so much to the characters. Surprises and plot twists along the way to keep you intrigued. There is some graphic sex, but is no way the focal point. Grammar was excellent (a rare find with a lot of self publishers) with only a few noted errors. I rarely give 4 stars, let alone 5.
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Reviewed in the United States on April 30, 2021
E
Verified Purchase
Elisa
San Leandro, US
★★★★★ 3
Sadly, DNF
Format: Kindle
I read this thru KU. I LOVED the synopsis. And then I began reading... and it was a DNF at 68% after picking it up and putting it down several times because I really loved the main female character. *****SPOILERS***** Pros: The world is unique, intriguing and fun. The primary female character is bad-a** but not a b*tech or a mary sue. The primary female has depth. I really want to know what happens to her even tho it's been weeks and I don't remember her name. The villains to the point I read are pretty good -- an ever present threat of mysterious and possibly many culprits. Cons: Way, way too many points of view. I stopped counting at 7. It's the prime reason why I don't care about most of the characters or remember their names even when I like them. There's just too many points of view so almost none of the characters have enough book space for the author to properly develop them. This literally killed the book for me. Actually it killed my desire to read. For weeks. The main male is more villain than hero. He agreed to marry the main female then locks her up & eschews her for her sister, all while bad mouthing her as unfit to rule when he never spent any time with her getting to know her. He is actually unfit to rule as he is blind to the woes of his own kingdom and starts off a peace mission to secure a ceasefire through marriage by murdering an inn full of people in her country for no real reason. Plus, he constantly makes promises he does not keep. And it's gross of him to pine for the sister behind the main female's back. ***** As much as I really wanted to see what happened to the main female character, it wasn't enough for me to keep trying to slog thru this book. There was a lot of potential here that just fell short. Hence, 3 stars.
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Reviewed in the United States on June 19, 2021
M
Verified Purchase
MaryBeth K
Belleville, US
★★★★★ 5
Fae Courts with High Intrigue
Format: Kindle
This book is one that just builds and builds and then surprises you to no end. You may think you know the villains and then you are jolted in another direction. Princess Reyna is a real gem, strong of character, a fierce fighter, and loyal to her family and kingdom. Just when you think she and Lorcan, well you know, the plot is flipped. Can't wait to see where this goes in book two.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 7, 2023

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