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Description
Mouse IgG2c Onestep ELISA KitProduct Specification Antigen IgG2c Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Ms Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 3. 2% Inter assay: 7. 2% Sample type Cell culture supernatant; Serum; Plasma Assay type Sandwich (quantitative) Sensitivity 3. 418 pg mL Range 39. 06 pg mL 2500 pg mL Recovery Cell culture supernatant: 89%
Product Specification
| Antigen | IgG2c |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Ms |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 3.2%； Inter-assay: 7.2% |
| Sample type | Cell culture supernatant; Serum; Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 3.418 pg/mL |
| Range | 39.06 pg/mL – 2500 pg/mL |
| Recovery | Cell culture supernatant: 89% Serum: 83% Plasma: 97% |
| Assay time | 60 minutes |
| Species reactivity | Ms |
Background
Mouse IgG2c is the functional equivalent and primary Th1-associated antibody isotype in C57BL/6 and related mouse strains, replacing the conventional IgG2a found in other strains like BALB/c. This expression is due to a natural allelic variation in the Igh-1 locus. Functionally, IgG2c mirrors IgG2a by exhibiting high affinity for activating Fc gamma receptors, making it exceptionally potent at eliciting effector mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC). Consequently, it is a critical mediator of protective immunity against intracellular pathogens and a key indicator of a robust Th1-type immune response in these specific mouse strains.
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