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Description
IDH1 Recombinant Rabbit mAb (S-792-16)Product Specification Host Rabbit Synonyms Isocitrate dehydrogenase [NADP] cytoplasmic, IDH, Cytosolic NADP isocitrate dehydrogenase, IDPc, NADP(+) specific ICDH, Oxalosuccinate decarboxylase, PICD Immunogen Synthetic Peptide Location Cytoplasm Accession O75874 Clone Number S 792 16 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Predicted Reactivity Or, Bv, Sh Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Synonyms | Isocitrate dehydrogenase [NADP] cytoplasmic, IDH, Cytosolic NADP-isocitrate dehydrogenase, IDPc, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | O75874 |
| Clone Number | S-792-16 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Or, Bv, Sh |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:2000 | |
| ICC | 1:500 |
Background
As an isocitrate dehydrogenase, IDH1 catalyzes the reversible oxidative decarboxylation of isocitrate to yield α-ketoglutarate (α-KG) as part of the TCA cycle in glucose metabolism. This step also allows for the concomitant reduction of nicotinamide adenine dinucleotide phosphate (NADP+) to reduced nicotinamide adenine dinucleotide phosphate (NADPH). Since NADPH and α-KG function in cellular detoxification processes in response to oxidative stress, IDH1 also indirectly participates in mitigating oxidative damage. In addition, IDH1 is key to β-oxidation of unsaturated fatty acids in the peroxisomes of liver cells. IDH1 also participates in the regulation of glucose-induced insulin secretion. Notably, IDH1 is the primary producer of NADPH in most tissues, especially in brain. Within cells, IDH1 has been observed to localize to the cytoplasm, peroxisome, and endoplasmic reticulum. Mutations in IDH1 have been shown to cause metaphyseal chondromatosis with aciduria. Mutations in IDH1 are also implicated in cancer.
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