SKU: 56913121215

Mouse Anti-Human CD8α Antibody (S-3972)

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Description

Mouse Anti-Human CD8α Antibody (S-3972)Product Specification Host Mouse Antigen CD8 Synonyms T cell surface glycoprotein CD8 alpha chain; T lymphocyte differentiation antigen T8 Leu 2; MAL; CD8A Location Secreted, Cell membrane Accession P01732 Clone Number S 3972 Antibody Type Mouse mAb Isotype IgG2a Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability &

Product Specification


Host Mouse
Antigen CD8α
Synonyms T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; MAL; CD8A
Location Secreted, Cell membrane
Accession P01732
Clone Number S-3972
Antibody Type Mouse mAb
Isotype IgG2a
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:2000 Hu

Background

CD8α is a crucial immune glycoprotein that plays a vital role in the immune response by serving as a co-receptor for the T-cell receptor (TCR) on cytotoxic T cells. It forms either a homodimer (α/α) or a heterodimer with CD8β (α/β) to interact with MHC class I molecules on antigen-presenting cells (APCs), facilitating the recognition of intracellular pathogens such as viruses. CD8α also recruits the LCK kinase, which initiates downstream signaling pathways essential for T-cell activation and proliferation. This molecule is critical for the function of cytotoxic T lymphocytes (CTLs) and is involved in various immune-related diseases, including immunodeficiencies and autoimmune conditions.

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SKU: 56913121215

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4.4 ★★★★★
Based on 25 reviews
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F
Verified Purchase
Faifre6
Boise, US
★★★★★ 5
Very detailed! Beautiful world building! Strong Heroine!
Format: Kindle
Starts off a little slow and confusing with different POV’s, but starts to all come together towards the middle to make an elaborate plot line and makes it all worth it. Beautiful world building and attention to detail as well as great writing. The cliffhanger was gut wrenching! Can’t wait for the next book!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 4, 2020
I
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Isabelle
Boise, US
★★★★★ 4
Interesting
Format: Kindle
This was a very captivating book once you got into it thoroughly. But the third person perspective was a bit hard to get used to. But as you got into it and followed the different characters, it was interesting and filled with intrigue, conflict and forbidden love. I can’t wait to read the next one and to complete the series.
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Reviewed in the United States on November 12, 2022
L
Verified Purchase
Lisa B.
Lowell, US
★★★★★ 5
OUTSTANDING
Format: Kindle
This was very, very good. The world is vast and characters are complex. There is a good plot with a whole lot going on. This is well written. Good twists and turns and some heart breaking moments. You will love these characters, they have heart and loyalty. I am hoping that there will be several more books. We've yet to see anything from the Sea Court but only a mention of them here and there. The Wood Court was given a quick couple of scenes, and only as far as some warriors, we've yet to enter their court and the Shadow Court, I'm not sure if they will be a force for good or bad, but they definitely will play a much bigger role moving forward. This is primarily the Ice and Air Courts. Told in multiple views, which I loved, it gives you a chance to see things from different eyes. There's alot of political maneuvering and deception. I loved it and will pick up the next book as it becomes available. If you like The Fae and the courts, you should love this. I think the author has mucn in store for us.
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Reviewed in the United States on March 8, 2020
J
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Jessika
Whiting, US
★★★★★ 4
Definitely worth the read!
Format: Kindle
After taking a deep breath and taking in that wicked twist of an ending, I have finally composed myself. My first thought when I started this book was that I love Reyna's character. I was intrigued by her connection with her familiar and the Ruin that is plaguing her land. It came as no surprise that she took her sister's place in an attempt to protect her. When they reach the Air Court everything slows down. This is where it was iffy for me. First of all, I like multiple POV's in books however 7 is a bit much. It starts to interrupt the story line. I felt like I was finally making progress connecting with one character, then it was switched to another person. I felt they all had necessary or pertinent information but not necessarily were they all POV worthy. The only other thing that annoyed me was that Reyna constantly was " trapped." She would rush off without thinking, only to need rescuing. She is brilliant in a fight, but she really doesn't think through anything. Lorcan is amazing. I know he might be on the "bad" list, but his background is so interesting. Eislyn(Reyna's sister) is really so sweet, but calculating. I enjoyed her and Thane's dialogue. The author did an amazing job with the imagery in this book. Everything was so detailed it was easy to fall into the scene. I love unexpected twists and while part of the ending I expected, I wasn't expecting how it took place. All in all, I found it very entertaining and I am very invested in continuing this series. Favorite quotes: "The truth may be twisted but never false." "Who was she if she was not the enemy of the Air Court? What was her purpose of she no longer has that?" "In a war-torn land, love was always a lie."
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Reviewed in the United States on March 4, 2020
K
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KAB
Charlottesville, US
★★★★★ 5
Great Read!!! Great story!!!
Format: Kindle
The series is long, but Ms. Wolfhart does a fantastic job of weaving this tale while bringing so much to the characters. Surprises and plot twists along the way to keep you intrigued. There is some graphic sex, but is no way the focal point. Grammar was excellent (a rare find with a lot of self publishers) with only a few noted errors. I rarely give 4 stars, let alone 5.
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Reviewed in the United States on April 30, 2021

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