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Description
IL-33 Full Length Protein, HumanProduct Specification Species Human Synonyms Interleukin 33,IL 33,Interleukin 1 family member 11 (IL 1F11),Nuclear factor from high endothelial venules (NF HEV), Accession O95760 Amino Acid Sequence Met1 Thr270, with N terminal His Tag Expression System E. coli Molecular Weight 33 kDa (Reducing) Purity >90% by SDS PAGE. Endotoxin <1EU g Conjugation Unconjugated Tag His Tag Storage Buffer 20mM Tris, 500mM L Arginine, 1mM DTT, pH8. 0 Reconstitution
Product Specification
| Species | Human |
| Synonyms | Interleukin-33,IL-33,Interleukin-1 family member 11 (IL-1F11),Nuclear factor from high endothelial venules (NF-HEV), |
| Accession | O95760 |
| Amino Acid Sequence | Met1-Thr270, with N-terminal His Tag |
| Expression System | E.coli |
| Molecular Weight | 33 kDa (Reducing) |
| Purity | >90% by SDS-PAGE. |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Storage Buffer | 20mM Tris, 500mM L-Arginine, 1mM DTT, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | J Immunol. 2012 Jul 1;189(1):403-10. |
Background
IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tissues and lymphoid organs, which plays important roles in type-2 innate immunity and human asthma. Recent studies indicate that IL-33 induces production of large amounts of IL-5 and IL-13 by group 2 innate lymphoid cells (ILC2s), for initiation of allergic inflammation shortly after exposure to allergens or infection with parasites or viruses. IL-33 appears to function as an alarmin (alarm signal) rapidly released from producing cells upon cellular damage or cellular stress.
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