Pay in installments of $79.38 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 23 - Jul 28
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
IKK gamma-Knockout HeLa Cell LysateProduct Specification Host Human Mutations 1bp (T213) deletion in exon 3 Application WB Concentration 2 mg ml Physical Appearance Liquid Storage Buffer Supplied in SDS Sample Buffer: 50 mM Tris HCl (pH 6. 8 at 25C), 2% w v SDS, 10% glycerol, 1% v v Mercaptoethanol, 0. 01% w v bromophenol blue or phenol red. Stability & Storage 20 C for 1 months under sterile conditions; 80 C for 24 months under sterile conditions. Please avoid repeated freeze thaw
Product Specification
| Host | Human |
| Mutations | 1bp (T213) deletion in exon 3 |
| Application | WB |
| Concentration | 2 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | Supplied in SDS Sample Buffer: 50 mM Tris-HCl (pH 6.8 at 25°C), 2% w/v SDS, 10% glycerol, 1% v/v β-Mercaptoethanol, 0.01% w/v bromophenol blue or phenol red. |
| Stability & Storage | -20 °C for 1 months under sterile conditions; |
Background
IKK-gamma, also known as NEMO or IKBKG, is a key regulatory protein with a molecular weight of approximately 46-50 kDa. Its structure is characterized by coiled-coil domains, enabling it to form a tetramer that functions as a molecular scaffold. The core biological function of Ikk-gamma is to serve as an essential regulatory subunit of the IKK kinase complex; it is responsible for receiving upstream signals and facilitating the assembly and activation of the complex. Within signaling pathways, Ikk-gamma orchestrates the activation of the canonical NF-κB pathway: upon cellular stimulation by agents such as TNFα or LPS, Ikk-gamma recognizes ubiquitination signals, leading to IKK complex activation. This, in turn, triggers the phosphorylation and subsequent degradation of the inhibitory protein IκB, ultimately releasing the NF-κB transcription factor for nuclear translocation. This process initiates the expression of genes involved in immunity, inflammation, and cell survival. Given its pivotal role, mutations in its gene can lead to immune disorders such as NEMO deficiency syndrome, and its dysregulation is intimately linked to cancer and chronic inflammatory diseases.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy