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Description
FGF-basic Protein, ChickenProduct Specification Species Chicken Synonyms Fibroblast growth factor 2, FGF 2, Basic fibroblast growth factor (bFGF), Heparin binding growth factor 2 (HBGF 2) Accession P48800 Amino Acid Sequence Pro13 Ser158 Expression System E. coli Molecular Weight 14 15 kDa (Reducing) Purity >95% by SDS PAGE & HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4 Reconstitution
Product Specification
| Species | Chicken |
| Synonyms | Fibroblast growth factor 2, FGF-2, Basic fibroblast growth factor (bFGF), Heparin-binding growth factor 2 (HBGF-2) |
| Accession | P48800 |
| Amino Acid Sequence | Pro13-Ser158 |
| Expression System | E.coli |
| Molecular Weight | 14-15 kDa (Reducing) |
| Purity | >95% by SDS-PAGE & HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | iScience. 2022 Sep 3;25(10):105054. |
Background
Basic fibroblast growth factor (bFGF), also known as FGF-2 or FGF-β, is a member of the fibroblast growth factor family that regulates essential biological functions including cell proliferation, survival, migration, and differentiation. The FGF family comprises 18-22 members grouped into subfamilies based on sequence homology, with FGF-2 binding to and signaling through all four FGF receptors (FGFR1-4), transmembrane receptors with intracellular tyrosine kinase activity. Upon activation, FGFRs recruit SH2 or PTB domain-containing signaling proteins, leading to activation of downstream pathways including RAS/MAP kinase, PI3 kinase/Akt, and PLCγ.
The industrial applications of chicken bFGF have expanded dramatically with the emergence of cellular agriculture and cultivated meat production. Recombinant chicken/duck FGF-2 protein (145 aa) is specifically developed for species-specific avian cellular agriculture protocols, serving as a critical medium component for cultivating chicken cells for food applications.
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