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Description
Lumican Recombinant Rabbit mAb (S-247-47)Product Specification Host Rabbit Antigen Lumican Synonyms Keratan sulfate proteoglycan lumican (KSPG lumican), LUM, LDC, SLRR2D Immunogen Synthetic Peptide Location Secreted Accession P51884 Clone Number S 247 47 Antibody Type Rabbit mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin
Product Specification
| Host | Rabbit |
| Antigen | Lumican |
| Synonyms | Keratan sulfate proteoglycan lumican (KSPG lumican), LUM, LDC, SLRR2D |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P51884 |
| Clone Number | S-247-47 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | |
| IHC | 1:2000 | |
| ICC | 1:500 | |
| ICFCM | 1:500 |
Background
Lumican, also known as LUM, is an extracellular matrix protein that, in humans, is encoded by the LUM gene on chromosome 12 [PMID: 7558030]. Lumican is a major keratan sulfate proteoglycan of the cornea but is ubiquitously distributed in most mesenchymal tissues throughout the body [PMID: 12975607]. Lumican is involved in collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. Corneal transparency is possible due to the exact alignment of collagen fibers by lumican (and keratocan) in the intrafibrillar space.
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