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Description
Rat Anti-Mouse IgD Antibody (S-R622)Product Specification Host Rat Antigen Mouse IgD Synonyms Ig delta chain C region membrane bound form Location Cell membrane Accession P01882 Clone Number S R622 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rat |
| Antigen | Mouse IgD |
| Synonyms | Ig delta chain C region membrane-bound form |
| Location | Cell membrane |
| Accession | P01882 |
| Clone Number | S-R622 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Ms |
Background
Immunoglobulin D (IgD) is one of the five classes of antibodies, primarily found as a monomer with a molecular weight of approximately 184 kDa and a half-life of 2.8 days. It is predominantly expressed on the surface of mature B cells, where it serves as an antigen receptor alongside IgM, playing a role in B cell activation, proliferation, and differentiation. IgD is also present in mucosal secretions and blood, and it can bind to basophils and mast cells, potentially activating them to release antimicrobial factors and contributing to mucosal immunity. Although its exact function remains enigmatic, IgD is believed to enhance humoral immune responses, participate in B cell memory, and possibly interfere with viral replication. Additionally, IgD may have a role in allergic reactions, though this area requires further investigation.
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