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Description
Invivo Anti-Mouse CXCR3 (CD183) Recombinant mAbProduct Specification Host Armenian hamster Antigen CXCR3 (CD183) Synonyms C X C chemokine receptor type 3; CXC R3; CXCR 3; Interferon inducible protein 10 receptor (IP 10 receptor); Cmkar3; Cxcr3 Location Cell membrane Accession O88410 Clone Number S 3758 Antibody Type Recombinant mAb Application FCM, in vivo CXCR3 neutralization Reactivity Ms Purification Protein G Concentration 5 mg ml Purity >95% (Determined by SDS PAGE) Endotoxin <1EU mg
Product Specification
| Host | Armenian hamster |
| Antigen | CXCR3 (CD183) |
| Synonyms | C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; Interferon-inducible protein 10 receptor (IP-10 receptor); Cmkar3; Cxcr3 |
| Location | Cell membrane |
| Accession | O88410 |
| Clone Number | S-3758 |
| Antibody Type | Recombinant mAb |
| Application | FCM, in vivo CXCR3 neutralization |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
CD183, also known as CXCR3, is a 40-kDa, seven-transmembrane G-protein-coupled receptor encoded on chromosome Xq13 that selectively binds the IFN-γ-inducible chemokines CXCL9, CXCL10 and CXCL11; upon ligation it triggers Gi-mediated signaling cascades (MAPK, PI3K/AKT, PLCβ3/μ-calpain, cAMP/PKA and p38MAPK) that induce rapid integrin activation, cytoskeletal rearrangement and chemotactic migration of activated/memory CD4⁺ and CD8⁺ T cells, NK cells and endothelial cells, thereby orchestrating Th1-oriented inflammatory responses, anti-viral immunity and angiostasis; the receptor exists in three alternatively spliced isoforms (CXCR3-A, -B and -alt) that differ in their C-termini and third intracellular loop, enabling ligand-specific functional bias—CXCR3-A promotes proliferation, survival and invasion, whereas CXCR3-B mediates growth inhibition, apoptosis and vascular suppression—and is prominently expressed in inflamed tissues and various cancers, making it a key therapeutic target for autoimmune, neoplastic and infectious diseases.
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