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Description
FGF-21 Protein, MouseProduct Specification Species Mouse Synonyms FGF 21, Fibroblast growth factor 21 Accession Q9JJN1 Amino Acid Sequence Ala29 Ser210 Expression System E. coli Molecular Weight 20kDa Purity >95% by SDS PAGE & RP HPLC Endotoxin <1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM PB, 150mM NaCl, pH 7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Mouse |
| Synonyms | FGF-21, Fibroblast growth factor 21 |
| Accession | Q9JJN1 |
| Amino Acid Sequence | Ala29-Ser210 |
| Expression System | E.coli |
| Molecular Weight | 20kDa |
| Purity | >95% by SDS-PAGE & RP-HPLC |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM PB, 150mM NaCl, pH 7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Kharitonenkov A J. et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest. 115(6): 1627-1635. 2、Guo A. et al. (2020) Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets? Exp Gerontol. 139: 111022. 3、Gomarasca M. et al. (2020) Myokines: The endocrine coupling of skeletal muscle and bone. Adv Clin Chem. 94: 155-218. |
Background
Fibroblast Growth Factor 21(FGF-21) is a member of the fibroblast growth factor (FGF) family and it is involved in the modulation of cell proliferation, growth, and differentiation as well as cell metabolism. This protein is a secreted endocrine factor that functions as a major metabolic regulator, and stimulates the uptake of glucose in adipose tissue. FGF21 binds to FGFR1c complexed with β-Klotho expressed in adipocytes to activate the canonical FGF signaling pathway (ERK1/2) and the AMPK/PGC1α pathway. Therefore, FGF-21 is being pursued as a therapeutic target for diabetes and obesity.
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