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Description
Human CD45, His tagProduct Specification Species Human Synonyms Receptor type tyrosine protein phosphatase C, Leukocyte common antigen (L CA), T200, PTPRC Accession P08575 Amino Acid Sequence Protein sequence(P08575, Gln26 Lys577, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen (L-CA), T200, PTPRC |
| Accession | P08575 |
| Amino Acid Sequence | Protein sequence(P08575, Gln26-Lys577, with C-10*His) QSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:62.4kDa Actual:100-150kDa |
| Purity | ＞95% by SDS-PAGE |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of co-stimulation), or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling. CD45 is a pan-leukocyte protein with tyrosine phosphatase activity involved in the regulation of signal transduction in hematopoiesis. CD45 does not colocalize with lipid rafts on murine and human non-transformed hematopoietic cells, but CD45 positioning within lipid rafts is modified during their oncogenic transformation to acute myeloid leukemia. CD45 colocalizes with lipid rafts on AML cells, which contributes to elevated GM-CSF signal intensity involved in proliferation of leukemic cells.
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4.4 ★★★★★
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Product Reviews
★★★★★ 5
Very nice quality and appearance
Color: Beige
They were surprisingly stout and went together well. We had to return them because when we took them to where they would be used, they were too big to work in that location. Dang. But if we needed them in the future, I wouldn't hesitate to purchase them.
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Reviewed in the United States on October 31, 2025
★★★★★ 3
Poor quality
Color: Grey
Temporary fix, poor quality, get what you pay for.
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Reviewed in the United States on November 22, 2025
★★★★★ 5
Good Multi-use Panels
Color: Grey
These panels were easy to assemble and stand sturdy. i will use them to block the sun when I am outside doing yard work in the heat. I'm sure I will find other uses for them too.
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Reviewed in the United States on November 14, 2025
★★★★★ 1
We threw it away
Color: Grey
This thing cannot stand on its own, the side bars bend since it is not sturdy enough to handle the material screens. After assembly, I was so mad at it, the pleasure of crushing it was better than returning it. I tryed to think of other ways to use it, but could not… i kept the screens, they are the strongest part of this thing. Very disappointing
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Reviewed in the United States on August 31, 2024
★★★★★ 3
Works well
Color: Beige
Does the trick for privacy and some noise blockage. This takes two people to put together. The construction make it easy to assemble, but makes it just as easy to come apart on its own.
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Reviewed in the United States on July 27, 2025
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