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Description
Nog1 Recombinant Rabbit mAb (S-R330)Product Specification Host Rabbit Antigen Nog1 Synonyms GTP binding protein 4, Chronic renal failure gene protein, GTP binding protein NGB, Nucleolar GTP binding protein 1, GTPBP4, CRFG Location Nucleus Accession Q9BZE4 Clone Number S R330 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | Nog1 |
| Synonyms | GTP-binding protein 4, Chronic renal failure gene protein, GTP-binding protein NGB, Nucleolar GTP-binding protein 1, GTPBP4, CRFG |
| Location | Nucleus |
| Accession | Q9BZE4 |
| Clone Number | S-R330 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC-P | 1:500 | null |
| ICC | 1:500 | null |
| ICFCM | 1:500 | null |
Background
Nog1 is a protein that in humans is encoded by the GTPBP4 gene. GTPases function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G protein-coupled receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.
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