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Description
FITC Armenian hamster Anti-Mouse CD48 Antibody (S-R654)Product Specification Host Armenian hamster Antigen Mouse CD48 Synonyms CD48 antigen; BCM1 surface antigen; BLAST 1; HM48 1; MRC OX 45 surface antigen; SLAM family member 2 (SLAMF2); Signaling lymphocytic activation molecule 2; sgp 60; Bcm 1 Location Cell membrane Accession P18181 Clone Number S R654 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0.
Product Specification
| Host | Armenian hamster |
| Antigen | Mouse CD48 |
| Synonyms | CD48 antigen; BCM1 surface antigen; BLAST-1; HM48-1; MRC OX-45 surface antigen; SLAM family member 2 (SLAMF2); Signaling lymphocytic activation molecule 2; sgp-60; Bcm-1 |
| Location | Cell membrane |
| Accession | P18181 |
| Clone Number | S-R654 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD48 (also known as SLAMF2) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein and a member of the signaling lymphocyte activation molecule (SLAM) family. It is expressed on various immune cells, including T cells, B cells, and natural killer (NK) cells. CD48 interacts with several ligands, such as CD2 and CD244 (2B4), to mediate immune cell adhesion, activation, and signaling. These interactions play crucial roles in T cell activation, NK cell cytotoxicity, and immune synapse formation. In disease contexts, CD48 expression is often upregulated in inflammatory conditions and certain cancers, such as acute myeloid leukemia (AML), where it may influence immune evasion and tumor progression. Additionally, CD48 has been identified as a potential biomarker and therapeutic target in autoimmune diseases, allergic conditions, and cancer immunotherapy.
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Exchange/Return Notes
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