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Description
Prohibitin Recombinant Rabbit mAb (S-2679-7)Product Specification Host Rabbit Antigen Prohibitin Synonyms Prohibitin 1; PHB; PHB1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession P35232 Clone Number S 2679 7 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample JAR, Jurkat, HepG2, HeLa, Daudi, T 47D, SH SY5Y, NIH 3T3, C6 Predicted Reactivity Ck Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | Prohibitin |
| Synonyms | Prohibitin 1; PHB; PHB1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | P35232 |
| Clone Number | S-2679-7 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | JAR, Jurkat, HepG2, HeLa, Daudi, T-47D, SH-SY5Y, NIH/3T3, C6 |
| Predicted Reactivity | Ck |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250-1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms, Rt |
Background
Prohibitin is a highly conserved, multifunctional protein complex—existing as two homologous subunits, PHB1 and PHB2—that localizes primarily to the inner mitochondrial membrane, nucleus, plasma membrane and cytosol, where it serves as a critical regulator of mitochondrial biogenesis, respiratory chain assembly and integrity, cellular senescence, apoptosis and lipid metabolism, while also acting as a transcriptional corepressor for nuclear receptors and a potential tumor suppressor, with deregulated expression implicated in obesity-linked metabolic disorders, neurodegenerative diseases and diverse cancers.
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