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Description
PE-Cy7 Rat Anti-Mouse CD115 Antibody (S-R562)Product Specification Host Rat Antigen CD115 Synonyms Macrophage colony stimulating factor 1 receptor; CSF 1 receptor (CSF 1 R; CSF 1R; M CSF R); Proto oncogene c Fms; Csfmr; Fms; Csf1r Location Cell membrane Accession P09581 Clone Number S R562 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample Fresh C57BL 6 mouse bone marrow Purification Protein G Concentration 0. 2 mg ml Conjugation PE Cy7 Physical Appearance Liquid
Product Specification
| Host | Rat |
| Antigen | CD115 |
| Synonyms | Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor (CSF-1-R; CSF-1R; M-CSF-R); Proto-oncogene c-Fms; Csfmr; Fms; Csf1r |
| Location | Cell membrane |
| Accession | P09581 |
| Clone Number | S-R562 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | Fresh C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PE-Cy7 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Ms |
Background
CD115, also known as CSF1R or colony stimulating factor 1 receptor, is a type I transmembrane protein encoded by the c-fms gene and belongs to the type III receptor tyrosine kinase family. It is primarily expressed on cells of the monocyte/macrophage lineage, dendritic cells, and in the developing placenta. CD115 acts as a receptor for colony stimulating factor 1 (CSF-1) and interleukin-34 (IL-34), mediating the biological effects of these cytokines on the survival, proliferation, and differentiation of myeloid cells, including macrophages and osteoclasts. The receptor consists of an extracellular domain with five immunoglobulin-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain. Mutations in the CD115 gene have been associated with a predisposition to myeloid malignancies.
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