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Description
PTK7/CCK4 His Tag Protein, MouseProduct Specification Species Mouse Synonyms PTK7, CCK4, Colon carcinoma kinase 4, Inactive tyrosine protein kinase 7, Tyrosine protein kinase like 7 Accession Q8BKG3 Amino Acid Sequence Ala23 Thr696, with C terminal 10*His
Product Specification
| Species | Mouse |
| Synonyms | PTK7, CCK4, Colon carcinoma kinase 4, Inactive tyrosine-protein kinase 7, Tyrosine-protein kinase-like 7 |
| Accession | Q8BKG3 |
| Amino Acid Sequence | Ala23-Thr696, with C-terminal 10*His AIVFIKEPSSQDALQGRRALLRCEVEAPDPVHVYWLLNGVPVQDTERRFAQGSSLSFAAVDRLQDSGAFQCVARDNVTGEEVRSTNASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDDQSTHTVSSRERNLTLRPASPEHSGLYSCCAHNAFGQACSSQNFTLSVADESFARVVLAPQDVVVARNEEAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLRRAVVFANGSLLLTQVRPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDMLPFEPRVFIAGDEERVTCPAPQGLPTPSVWWEHAGVPLPAHGRVHQKGLELVFVTIAESDTGVYTCHASNLAGQRRQDVNITVATVPTWLRKPQDSQLEEGKPGYLHCLTQATPKPTVIWYRNQMLISEDSRFEVSKNGTLRINSVEVYDGTLYRCVSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTVKWVRADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNEPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLRCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGSYTCIAGNSCNIRHTEAPLLVVDKPVMEDSEGPGSPPPYKMIQTGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 95-110kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Lichtig H. et al. (2019) Ptk7 proteolytic fragment proteins function during early xenopus development. Dev Biol. 453(1): 48-55. 2、Damelin M. et al. (2017) A ptk7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions. Sci Transl Med 9 (372): eaag2611. |
Background
Protein tyrosine kinase 7 (PTK7), also known as colon carcinoma kinase 4 (CCK4), is a member of the receptor tyrosine kinase superfamily. PTK7 is a type I transmembrane receptor with a large extracellular domain (ECD) containing 7 Ig-like C2 type loops, a transmembrane domain, and a cytoplasmic tyrosine kinase homology domain. PTK7 has been shown to be an important regulator of the Wnt signaling pathways, both canonical and non-canonical, and is linked to the regulation of the planar cell polarity pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
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4.3 ★★★★★
Based on 28 reviews
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Product Reviews
★★★★★ 5
Soft, comfortable!
Size: Throw(51" x 63"), Color: Cream White
The softest blanket we own! Definitely seems durable and so warm, love that it doesn’t shed and the material has held up well after a couple of washes, I wasn’t sure about the price but it is our favorite now.
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Reviewed in the United States on May 16, 2026
★★★★★ 5
Luxury and priced so well.
Size: 60''x80'', Color: Tipped Champagne Ivory
Absolutely gorgeous. Its got some weight to it, which I love, so cuddly. Nice quality velvet lines the underside in a beige color. Well done. Looks and feels so luxurious. The color is as in the picture, has dimension when its rumpled, but fully creamy white when laying flat. I can't figure it out how that happens lol! But its lovely.
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Reviewed in the United States on March 29, 2026
★★★★★ 5
Buy it!
Size: 60''x80'', Color: Tipped Champagne Ivory
So soft and perfect weight! The color is beautiful and it feels luxury!! Great value for money and the size is perfect. Fits over my king bed nicely, not enough to be an actual king size blanket but it’s enough to cover the main part of the bed and add extra warmth!
Mine did shed a little out of the bag, but I just put it in the dryer with some dryer sheets (no heat) for an hour and that did the trick!
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Reviewed in the United States on March 24, 2026
★★★★★ 5
Absolutely Stunning!!!
Size: 60''x80'', Color: Ombré Silver Onyx
Gorgeous blanket. Very warm and so soft. The softest blanket I've ever owned. Love the color. It's very light (in weight) while laying under it making it so comfortable - and yet - very comfortably Warm! I live in the north east of the U.S. and nights can get very cold.
This blanket is perfect! So beautiful. So soft. I love it! Thumbs Up!!!
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Reviewed in the United States on February 14, 2026
★★★★★ 5
Luxury faux fir blanket
Size: 60''x80'', Color: Tipped Champagne Ivory
Can’t say enough about this beautiful, so soft well made blanket! The size is perfect laying on our king size bed. The BEST purchase. Love the soft color and NO shedding!
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Reviewed in the United States on December 28, 2025
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