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Description
DGKA Recombinant Rabbit mAb (S-1933-121)Product Specification Host Rabbit Antigen DGKA Synonyms Diacylglycerol kinase alpha; DAG kinase alpha; 80 kDa diacylglycerol kinase; Diglyceride kinase alpha (DGK alpha); DAGK; DAGK1 Immunogen Synthetic Peptide Location Cytoplasm Accession P23743 Clone Number S 1933 121 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Positive Sample Jurkat, HeLa, HEK 293, Molt 4 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | DGKA |
| Synonyms | Diacylglycerol kinase alpha; DAG kinase alpha; 80 kDa diacylglycerol kinase; Diglyceride kinase alpha (DGK-alpha); DAGK; DAGK1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P23743 |
| Clone Number | S-1933-121 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu |
| Positive Sample | Jurkat, HeLa, HEK-293, Molt-4 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| ICC | 1:100 | Hu |
Background
Diacylglycerol kinase alpha (DGKA) is an enzyme encoded by the DGKA gene in humans and belongs to the eukaryotic diacylglycerol kinase family. It is involved in intracellular signaling pathways, acting as a modulator that competes with protein kinase C for the second messenger diacylglycerol. DGKA also plays a crucial role in the resynthesis of phosphatidylinositols and the phosphorylation of diacylglycerol to phosphatidic acid. Additionally, DGKA has been identified as a potential candidate in radiation-induced fibrosis, where its expression can be induced by the transcription factor EGR1, leading to enhanced production of pro-fibrotic ECM proteins such as collagen and fibronectin.
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