SKU: 61414280144

Alexa Fluor® 488 Mouse Anti-Human TIGIT Antibody (S-R730)

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Description

Alexa Fluor® 488 Mouse Anti-Human TIGIT Antibody (S-R730)Product Specification Host Mouse Antigen TIGIT Synonyms T cell immunoreceptor with Ig and ITIM domains; V set and immunoglobulin domain containing protein 9; V set and transmembrane domain containing protein 3; VSIG9; VSTM3 Location Cell membrane, Synapse Accession Q495A1 Clone Number S R730 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Purification Protein A Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer

Product Specification


Host Mouse
Antigen TIGIT
Synonyms T-cell immunoreceptor with Ig and ITIM domains; V-set and immunoglobulin domain-containing protein 9; V-set and transmembrane domain-containing protein 3; VSIG9; VSTM3
Location Cell membrane, Synapse
Accession Q495A1
Clone Number S-R730
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Purification Protein A
Conjugation Alexa Fluor® 488
Physical Appearance Liquid
Storage Buffer

PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

Stability & Storage 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5 μl per million cells in 100μl volume

Background

TIGIT (T cell immunoglobulin and ITIM domain) is an inhibitory receptor expressed on lymphocytes, including natural killer (NK) cells and various subsets of T cells such as CD4+ T cells, CD8+ T cells, and regulatory T cells. It was discovered in 2009 through genome-wide analysis aiming to identify proteins containing domain structures typical for immunomodulatory receptors. TIGIT consists of one extracellular immunoglobulin variable domain, a type I transmembrane domain, and a short intracellular domain with one immunoreceptor tyrosine-based inhibitory motif (ITIM) and one immunoglobulin tyrosine tail (ITT)-like motif. Its main ligand is CD155, also known as poliovirus receptor (PVR), but it can also bind to CD112 and CD113 with lower affinity. TIGIT plays a significant role in down-regulating T cell and NK cell functions by interacting with these ligands expressed on antigen-presenting cells or tumor cells. This interaction inhibits immune cell responses at multiple steps of the cancer-immunity cycle, such as impairing T cell priming by dendritic cells, preventing tumor cell killing by NK cells and cytotoxic T cells, and enhancing the immune suppressive activity of regulatory T cells. Therefore, TIGIT has emerged as a major target in cancer immunotherapy. Several monoclonal antibodies that block the inhibitory activity of human TIGIT have been developed, and clinical trials are ongoing to investigate TIGIT blockade as a monotherapy or in combination with anti-PD1/PD-L1 antibodies for the treatment of patients with advanced solid malignancies.

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SKU: 61414280144

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4.3 ★★★★★
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madison
Battle Creek, US
★★★★★ 5
nice quality
Fit Type: Regular Fit, Color: White, Size: Small
nice quality shirt. bought this just so i had at least one nice white button down and it's great. fits well and is a nice white color.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 11, 2026
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Jerry
San Leandro, US
★★★★★ 5
A perfect white work shirt.
Fit Type: Regular Fit, Color: White, Size: Medium
Thick, durable, iron exquisitely and the fit is spot on. Perfect white work shirt. I have a grey shirt too, the quality is the same.
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Reviewed in the United States on March 4, 2026
B
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Blusher
Belleville, US
★★★★★ 3
Right fit
I love this shirt it was nice and bright when I got it after a few wash it started to fade out a bit was a perfect fit for a medium built person 5’7 I still would recommend this product they are really nice and thick
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Reviewed in the United States on September 14, 2025
L
Verified Purchase
Linda Mokkosian
Charlottesville, US
★★★★★ 5
Excellent value and has saved me from the sun!
Fit Type: Regular Fit, Color: White, Size: Large
I ordered this large mans shirt because it was 100% cotton and long sleeve. I am a woman and use it to protect myself from the sun walking my dog, very stiff at first, but comes out with several washes. I love the shirt!
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Reviewed in the United States on June 9, 2026
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Wilf
Lowell, US
★★★★★ 4
NICE Shirt that SHRINKS!!
Fit Type: Regular Fit, Color: Blue, Size: X-Large
Loved this shirt right out of the package. Put a little steam pressing on it and it was perfect. Has a thicker softer feel than most casual dress shirts. Ordered XL with the "regular" fit and it could be worn tucked or out without it looking overly blousy. SADLY, after a first wash on cold and tumble dry low, and pulled it out early and it shrunk by almost a full size!!! The sleeves, length of shirt and overall fittage shrunk so that now it fits like a snug large. I've never had a shirt shrink like this, hence, the one star off. I would have given it 2 stars off, but the original quality of the shirt is nice, just beware of the shrinkage factor. Don't put it in the dryer at all, only air dry it. I'm tempted to reorder another but just then never put it in the dryer.
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Reviewed in the United States on May 23, 2026

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