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Description
S-RMab® PMS2 Recombinant Rabbit mAb,PBS Only(SDT-R460)Product Specification Host Rabbit Antigen PMS2 Synonyms Mismatch repair endonuclease PMS2; DNA mismatch repair protein PMS2; PMS1 protein homolog 2 Location Nucleus Accession P54278 Clone Number SDT R460 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of
Product Specification
| Host | Rabbit |
| Antigen | PMS2 |
| Synonyms | Mismatch repair endonuclease PMS2; DNA mismatch repair protein PMS2; PMS1 protein homolog 2 |
| Location | Nucleus |
| Accession | P54278 |
| Clone Number | SDT-R460 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:4000 | |
| IHC-P | 1:100-1:250 | |
| ICC | 1:2000 | |
| ICFCM | 1:200 |
Background
This gene is one of the PMS2 gene family members which are found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. The protein forms a heterodimer with MLH1 and this complex interacts with MSH2 bound to mismatched bases. Defects in this gene are associated with hereditary nonpolyposis colorectal cancer and Turcot syndrome. So joint detection of MLH1, MSH2, PMS2, and MSH6 can be used for screening of hereditary non polypic colon cancer (Lynch syndrome).
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