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Description
GDNF Receptor alpha 1/GFRA1 Recombinant Rabbit mAb (S-3289-52)Product Specification Host Rabbit Antigen GDNF Receptor alpha 1 GFRA1 Synonyms GDNF family receptor alpha 1; GDNF receptor alpha 1; GDNFR alpha 1; GFR alpha 1; RET ligand 1; TGF beta related neurotrophic factor receptor 1; GDNFRA; RETL1; TRNR1 Immunogen Synthetic Peptide Location Endosome, Cell membrane Accession P56159 Clone Number S 3289 52 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample MCF7
Product Specification
| Host | Rabbit |
| Antigen | GDNF Receptor alpha 1/GFRA1 |
| Synonyms | GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1; GDNFRA; RETL1; TRNR1 |
| Immunogen | Synthetic Peptide |
| Location | Endosome, Cell membrane |
| Accession | P56159 |
| Clone Number | S-3289-52 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | MCF7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
GDNF family receptor alpha-1 (GFRA1) is a 465-amino-acid, glycosylphosphatidylinositol-anchored cell-surface glycoprotein that functions as the high-affinity ligand-binding component for glial-cell-line-derived neurotrophic factor (GDNF) and its close homolog neurturin; upon ligand binding GFRA1 nucleates formation of a tripartite complex that recruits and trans-activates the transmembrane tyrosine kinase RET, thereby triggering downstream survival, proliferation and neurite-outgrowth signals (PI3K/AKT, RAS/MAPK, PLCγ) in dopaminergic, motor, sensory and enteric neurons, and this same GFRA1-mediated signaling is essential during kidney morphogenesis, spermatogenesis and peripheral-nerve repair while also being implicated in cancer chemoresistance and Parkinson’s disease.
Shipping Notes
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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