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Description
Cyclin D3 Recombinant Rabbit mAb (SDT-R124)Product Specification Host Rabbit Antigen Cyclin D3 Synonyms G1 S specific cyclin D3, CCND3 Immunogen N A Location Cytoplasm, Nucleus Accession P30281 Clone Number SDT R124 Antibody Type Rabbit mAb Application WB, IHC P, ICC, ICFCM, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rabbit |
| Antigen | Cyclin D3 |
| Synonyms | G1/S-specific cyclin-D3, CCND3 |
| Immunogen | N/A |
| Location | Cytoplasm, Nucleus |
| Accession | P30281 |
| Clone Number | SDT-R124 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:250-1:500 | null |
| WB | 1:1000 | null |
| IP | 1:50 | null |
| ICFCM | 1:500 | null |
| ICC | 1:500 | null |
Background
Transitions through the cell cycle are driven by cyclins and cyclin-dependent kinases (CDKs) [PubMed: 26658964]. Cyclins are the allosteric activators of cognate CDKs; their levels typically oscillate across the cell cycle, hence gaining the name cyclins. . The cyclin family shares a homologous N-terminal 100-amino acid motif referred as the cyclin box that has a highly conserved three-dimensional structure and provides the binding interface for the appropriate CDKs [PubMed: 8591034]. D cyclins, including cyclins D1, D2 and D3, form active complexes with either CDK4 or CDK6, which in turn phosphorylate the retinoblastoma protein (Rb) and drive G1 to S phase progression [PubMed: 7505440].
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