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Description
FITC Rat Anti-Mouse IL-17A Antibody (S-R683)Product Specification Host Rat Antigen IL 17A Synonyms Interleukin 17A; IL 17; Cytotoxic T lymphocyte associated antigen 8 (CTLA 8); Ctla8; Il17; Il17a Location Secreted Accession Q62386 Clone Number S R683 Antibody Type Rat mAb Isotype IgG1,k Application ICFCM Reactivity Ms Positive Sample Th17 Polarization C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 1% BSA,
Product Specification
| Host | Rat |
| Antigen | IL-17A |
| Synonyms | Interleukin-17A; IL-17; Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8); Ctla8; Il17; Il17a |
| Location | Secreted |
| Accession | Q62386 |
| Clone Number | S-R683 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | ICFCM |
| Reactivity | Ms |
| Positive Sample | Th17 Polarization C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 5μl per million cells in 100μl volume | Ms |
Background
IL-17A protein a is key cytokine produced by various immune cells such as Th17 cells. It plays a crucial role in the immune response by promoting inflammation. It can induce the expression of various pro-inflammatory molecules in different cell types, including chemokines that recruit neutrophils and other immune cells to the site of infection or injury. IL-17A is involved in the defense against certain pathogens, but its excessive production is also associated with the pathogenesis of several autoimmune and inflammatory diseases like psoriasis and rheumatoid arthritis. Targeting IL-17A has become an important therapeutic strategy in the treatment of these conditions.
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4.8 ★★★★★
Based on 8 reviews
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Product Reviews
★★★★★ 5
Dog Approved - Highly Preferred Over Standard Toothbrush
Color: Neon (4-pack)
These pet finger tooth brushes work well for me and my dog. He most definitely tolerates these so much more than a standard tooth brush. I believe I am able to reach more of his teeth and that I'm more effective brushing with these than I am with a standard brush. I put one on each of my index fingers. This makes it easier to do each side and the top and bottom without having to twist and turn to reach everything. The size is just right for my index fingers. They are a little tight getting them on and I have found that wetting my finger and the inside of the finger brush makes it a lot easier to put them on. The bristles on the finger brushes are soft, yet they are durable enough to give some good scrub quality and gum massage. These are a good price for what you get. I purchased the four-pack at right about $16.00. I have gotten numerous uses so far out of the two that I have been using. I will definitely purchase these again when it is time.
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Reviewed in the United States on July 13, 2025
★★★★★ 4
Probably Best for Medium-Large Size Dogs
Color: Blue (2-pack)
This finger cot–style toothbrush works well and is a simple way to brush your dog’s teeth, especially if they’re not comfortable with a traditional toothbrush. The material is soft yet effective at cleaning, and it gives you good control while brushing.
The only drawback is that it’s a little large for my miniature Dachshund’s mouth, making it somewhat difficult to reach all areas comfortably. It would probably be a better fit for medium or larger dogs. Even so, it gets the job done and is a good option for introducing dogs to regular dental care.
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Reviewed in the United States on May 31, 2026
★★★★★ 5
The easiest and best tooth brush!
Color: Pink (2-pack)
Ive tried several other dog tooth brushes for my 74 lbs Coonhound. This style and brand is the only one that is easy and works for us. It's easy to move your finger around and all sides of it have the cleaning nodules so no matter which way your finger turns, they are always touching her teeth. I like to try to open her mouth and get the inside of the mouth too. I loop my finger around her fangs. It is soft without harder parts so it doesn't make her pull away. This brush is perfect. It's a good quality and comes with a container for storage.
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Reviewed in the United States on March 3, 2026
★★★★★ 5
Total GAME CHANGER - incredibly effective toothbrush for dogs
Color: Clear (2-pack)
This silicon finger brush is incredibly easy to use - and so EFFECTIVE (more on that in the last paragraph this review). At first, it seemed a little hard to get on my finger but I simply got my finger wet first under the faucet and it slipped right on with virtually no effort. And once on, it's easy to take off but doesn't slip off accidentally when in use - so - perfect! Quick & simply to clean - rinses off in the sink in seconds, and ready to use the next time. And, my dog not only lets me clean her teeth - she actually like it (this from a dog who used to hate it when I would try to brush her teeth with a regular doggy toothbrush).
This silicon "brush" is incredibly maneuverable - way more so than standard dog toothbrushes or regular finger brushes. So much so it makes it super easy to not only get those normally impossible to reach back molars - AND - even the back sides of the teeth! With a normal dog tooth brush (or finger brush) my dog's clamping down made that impossible. Now, it's not only possible - it's easy!
Our dog's canine teeth had build-up but it was not until I pulled her gums back and looked at her back molars that I saw how bad things had gotten - and we have a young dog! Her back molars not only had build-up but some appeared to be stained a tea colored brown that did not come off with my fingernail. It was pretty disheartening and I felt terrible. How could this happen so quickly? The vet said it was plaque (and not yet tartar) and that it wasn't bad enough to warrant a professional cleaning - yet - but that I needed to do a better job brushing. He said: "I can see exactly where your brushing stops" (referring to the condition on the back molars which I had not been able to do with a regular brush as my dog just wasn't having it).
Tips: here's what's working for us. Instead of squeezing out a pea sized blog of tooth paste onto this brush, I put a tiny dab - that it's - on the very tip of the brush and focus my efforts on two of our dog's worst teeth on one side - on top and then on the bottom. Then I put another small dab and repeat on the other side of her mouth with 4 teeth on that side. Then, I use another small dab and focus work on another group of teeth. All totaled, I'm using maybe 4 to 6 very small dabs of dog toothpaste, probably half the size of pea collectively, perhaps less. That's it. However much you choose to use is up to you - be sure and use an amount that's safe and effective for your dog.
Effectiveness: this works and it works well! In just 3 days using the same vanilla flavored enzymatic toothpaste by CET I was seeing improvement. By day 7, that improvement was so obvious I was actually surprised by how much better they looked. It's now been a little over two weeks and they are looking considerably better! Conservatively, I'm thinking a 50% improvement. Not bad for just 2 weeks, right? I'm actually think I'm going to be able to completely reverse things - we'll see. I'll try and update this review again in a few weeks and let you know how it's looking but in the meantime, I am absolutely thrilled with this brush. I paid $16 and it came 2 in a pack) and the first (and only one) I've been using still looks brand new after it's rinsed off. All in all - this brush is a game changer! I can now brush our dogs back teeth and even the back sides of her teeth, all in less than a couple minutes a day.
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Reviewed in the United States on August 23, 2020
★★★★★ 3
Plastic not a brush
Color: Clear (4-pack)
Love the idea, dont care for the texture. It would be nice if they were soft brush and not plastic.
Would retuen but i missed the window.
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Reviewed in the United States on May 22, 2026