Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 9 - Aug 14
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
CRBN Recombinant Rabbit mAb (S-2044-2)Product Specification Host Rabbit Antigen CRBN Synonyms Protein cereblon Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q96SW2 Clone Number S 2044 2 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample U266B1, HCT 116, PC 3, NIH 3T3, C6 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | CRBN |
| Synonyms | Protein cereblon |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q96SW2 |
| Clone Number | S-2044-2 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | U266B1, HCT 116, PC-3, NIH/3T3, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
Cereblon (CRBN), encoded by the CRBN gene located on chromosome 3p26.2, is an evolutionarily conserved 442-amino-acid substrate receptor of the CRL4A E3 ubiquitin ligase complex, which ubiquitinates target proteins for proteasomal degradation, thereby influencing developmental processes (e.g., limb and auditory vesicle formation), regulating potassium channels, and modulating immune functions, including T-cell proliferation and activation. CRBN also serves as the primary molecular target for thalidomide and its immunomodulatory drug derivatives (lenalidomide, pomalidomide), which inhibit CRBN autoubiquitination and modulate ubiquitination of downstream substrates, thereby exerting anti-myeloma and teratogenic effects. Mutations or dysregulation of CRBN are linked to autosomal recessive nonsyndromic mental retardation and may affect cell metabolism and disease development.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy