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Description
IgG1 Fc (NNAS) Protein, HumanProduct Specification Species Human Synonyms IgG1 Fc, Ig gamma 1 chain C region, IGHG1 Accession P01857 Amino Acid Sequence Thr21 Ile192 (S82N, T83A, Y84S) PKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNNASRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK Expression System HEK293 Molecular Weight 30 33kDa Purity >95% by
Product Specification
| Species | Human |
| Synonyms | IgG1 Fc, Ig gamma-1 chain C region, IGHG1 |
| Accession | P01857 |
| Amino Acid Sequence | Thr21-Ile192 (S82N, T83A, Y84S) PKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNNASRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 30-33kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Immunoglobulin G (IgG) is one of the most abundant proteins in human serum, accounting for about 10–20% of plasma protein. Immunoglobulin G (IgG) is a monomer immunoglobulin, mainly involved in secondary antibody reaction, plasma B cell synthesis and secretion, constitute 75% of human serum immunoglobulin. There are four subtypes of human IgG antibodies: IgG1, IgG2, IgG3, IgG4; mice IgG can be divided into five subtypes; IgG1, IgG2A, IgG2B, IgG2C and IgG3; rats have four subtypes: IgG1, IgG2A, IgG2B and IgG2C. The nomenclature of IgG subtypes of different species is independent, so there is no correlation among different genera. The content of IgG1 in serum accounts for about 60%, and the half-life in serum is about 21 days. After pepsin cleavage, IgG1 is divided into two antigenic binding sites F (ab) s and a highly conserved Fc fragment, and Fc has a highly conserved N-glycosylation site. IgG1 is the most potential subtype in tumor immunotherapy. The active form of IgG1 is bivalent monomer, and human IgG1 can also bind to mouse Fc γ receptor, so the obvious effect can be observed in mouse model.
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Exchange/Return Notes
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4.7 ★★★★★
Based on 16 reviews
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Product Reviews
★★★★★ 5
Great Chew Toy for Destructive Dogs
I got this toy for our lab/pit mix, who tends to destroy most chew toys. He seems to really enjoy it so far, preferring it over his other toys. I'm not sure if it’s just the novelty of a new toy, or whether he actually likes the "real beef flavor," but either way, he's definitely into it.
I’ve noticed some small teeth marks in the rubber, but nothing that concerns me too much at this point. My kids thought it looked pretty gross when I first pulled it out, which always makes me laugh! Overall, I'm very satisfied with the toy’s performance so far. It seems durable and I hope it lasts a long time--based on how things are going, I think it will. It's definitely worth the price.
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Reviewed in the United States on February 7, 2026
★★★★★ 5
Unusual looking, but durable and the pup likes it.
From the moment I took the box containing this toy out of its shipping box, my dog went nuts. He was not going to wait and had to have it NOW. Clearly the scent was quite appealing (if you’re a dog). He’s had it for a week now and he continues to enjoy it. This “meat bone” may not look appetizing to us, but my pup chews it regularly. The grooves and ridges seem to be interesting to him, and likely help with his dental health. The bone has held up quite well so far. My dog is an aggressive chewer and this one remains in good shape. Unlike plastic ones that leave a lot of sharp pieces all over - this one stays intact. Recommend.
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Reviewed in the United States on February 4, 2026
★★★★★ 5
Easy to use
I love these. Not only do they work at reducing any blemish size and inflammation, they are practically invisible like advertised.
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Reviewed in the United States on April 29, 2026
★★★★★ 5
Really help soothe redness and speed up healing
I've been using these patches for a while now and I'm very happy with them - they're virtually invisible on the skin, stay on well and really help soothe redness and speed up healing.
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Reviewed in the United States on April 8, 2026
★★★★★ 5
My kid loves them!
My kid loves these. They also said they like that, unlike some other ones, they can see underneath it somewhat to tell when its more ready to come off.
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Reviewed in the United States on April 5, 2026