SKU: 6469880279

PE Mouse Anti-human HLA-ABC Antibody (S-R526)

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Description

PE Mouse Anti-human HLA-ABC Antibody (S-R526)Product Specification Host Mouse Antigen HLA ABC Synonyms HLA class I histocompatibility antigen; A alpha chain; Human leukocyte antigen A (HLA A); HLA class I histocompatibility antigen; B alpha chain; Human leukocyte antigen B (HLA B); HLA class I histocompatibility antigen, C alpha chain; HLA Cw; Human leukocyte antigen C Location Cell membrane Accession P04439P01889P10321 Clone Number S R526 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM

Product Specification


Host Mouse
Antigen HLA-ABC
Synonyms HLA class I histocompatibility antigen; A alpha chain; Human leukocyte antigen A (HLA-A); HLA class I histocompatibility antigen; B alpha chain; Human leukocyte antigen B (HLA-B); HLA class I histocompatibility antigen, C alpha chain; HLA-Cw; Human leukocyte antigen C
Location Cell membrane
Accession P04439、P01889、P10321
Clone Number S-R526
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample human peripheral blood Leukocytes
Purification Protein A
Concentration 0.2 mg/ml
Conjugation PE
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1.25μl per million cells in 100μl volume Hu

Background

HLA-ABC (also termed HLA class I classical heavy chains A, B, and C) are 44 kDa type I transmembrane glycoproteins encoded within the major histocompatibility complex on chromosome 6p21.3; each non-covalently associates with the invariant light chain β2-microglobulin (12 kDa) to form a peptide-binding heterodimer that is constitutively expressed on nearly all nucleated cells. These molecules serve as the principal conduit for presenting endogenously derived 8–11-mer peptides to CD8⁺ cytotoxic T lymphocytes, thereby orchestrating immune surveillance against intracellular pathogens, tumors, and transplanted tissues. Polymorphic residues concentrated in the α1 and α2 domains create an extraordinary diversity (thousands of alleles catalogued in the IPD-IMGT/HLA database), which underpins population-level resistance to infection yet constitutes the primary barrier to solid-organ and hematopoietic stem-cell transplantation through allorecognition. Beyond antigen presentation, HLA-ABC interacts with NK-cell inhibitory receptors (KIR and LILRB1) to calibrate natural killer cell responses, and its surface levels are dynamically modulated by cytokines such as interferon-γ, viral immune evasion proteins (e.g., HIV Nef, CMV US2/US11), and oncogenic signaling pathways, making quantitative HLA-ABC expression a prognostic biomarker in cancer immunotherapy.

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SKU: 6469880279

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Vicki Fontana
Boise, US
★★★★★ 5
One size smaller is perfect!
Color: Navy, Size: 10 Years
This suit fit perfect but I did order one size smaller than my grandson normally wears. It is very well made and he can't wait to wear it in the wedding.
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Reviewed in the United States on March 19, 2026
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Laurie Rygiel
Dallas, US
★★★★★ 5
Suit
Color: Beige, Size: 10 Years
Our grandson looked so handsome!
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Reviewed in the United States on May 6, 2026
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TG88
Lowell, US
★★★★★ 3
Fits wide
Color: Navy, Size: 7 Years
Nice suit but fits wide IMO
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Reviewed in the United States on June 5, 2026
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Love the dress
Alexandria, US
★★★★★ 5
Awesome quality for the price
Color: Black, Size: 8
Ordered size 8 for my son first communion great fit for the price was excellent
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Reviewed in the United States on May 4, 2026
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Phoenix, US
★★★★★ 5
Perfect fit and great quality for the price
This suit was perfect for my son. The fit was exactly as expected. The quality is excellent for the price—it feels well made and durable enough to last through multiple wears. It doesn’t feel cheap or flimsy at all. It also looks really good on him. Clean, polished, and great for formal events like weddings or parties. Overall, a fantastic value with great quality and a great fit.
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Reviewed in the United States on May 9, 2026

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