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Description
Alexa Fluor® 647 Mouse Anti-Human CD304 Antibody (S-R695)Product Specification Host Mouse Antigen CD304 Synonyms Neuropilin 1; Vascular endothelial cell growth factor 165 receptor; NRP; VEGF165R; NRP1 Location Cytoplasm, Mitochondrion, Cell membrane Accession O14786 Clone Number S R695 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Purification Protein A Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300 Stability &
Product Specification
| Host | Mouse |
| Antigen | CD304 |
| Synonyms | Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; NRP; VEGF165R; NRP1 |
| Location | Cytoplasm, Mitochondrion, Cell membrane |
| Accession | O14786 |
| Clone Number | S-R695 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein A |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume |
Background
CD304, also known as neuropilin-1 (NRP-1) or BDCA-4, is a type I transmembrane protein that plays crucial roles in various biological processes. It is a non-tyrosine kinase C-type lectin receptor, first identified on the cell membrane of plasmacytoid dendritic cells (pDCs). CD304 is involved in neuronal guidance during embryogenesis, angiogenesis, and immune responses. It serves as a co-receptor for vascular endothelial growth factor (VEGF) and members of the semaphorin family, interacting with plexins and VEGF receptors on neurons and endothelial cells. In the immune system, CD304 is expressed on natural Treg cells and may contribute to immunosuppression and tumor growth regulation. Additionally, CD304 is a valuable marker for distinguishing residual disease in B-cell acute lymphoblastic leukemia (B-ALL) and is widely used in minimal residual disease (MRD) detection.
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