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Description
Mouse CXCL1/KC Onestep ELISA KitProduct Specification Antigen CXCL1 KC Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Ms Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 2. 7% Inter assay: 3. 2% Sample type Cell culture supernatant, Serum, Plasma Assay type Sandwich (quantitative) Sensitivity 0. 548 pg mL Range 1. 563 pg mL 100 pg mL Recovery Cell culture supernatant:
Product Specification
| Antigen | CXCL1/KC |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Ms |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 2.7%； Inter-assay: 3.2% |
| Sample type | Cell culture supernatant, Serum, Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 0.548 pg/mL |
| Range | 1.563 pg/mL – 100 pg/mL |
| Recovery | Cell culture supernatant: 110% Serum: 92% Plasma: 109% |
| Assay time | 60 minutes |
| Species reactivity | Ms |
Background
Mouse CXCL1, also known as KC (keratinocyte-derived chemokine), is a key member of the CXC chemokine family primarily secreted by macrophages, fibroblasts, and endothelial cells in response to pro-inflammatory stimuli such as IL-1β or TNF-α. It functions as a potent chemoattractant by binding to its receptor CXCR2, which is predominantly expressed on neutrophils, thereby orchestrating the rapid recruitment of these immune cells to sites of infection, tissue injury, or inflammation. This protein plays a critical role in acute inflammatory responses, contributing to host defense against bacterial and fungal pathogens. Beyond infection, CXCL1 is also implicated in various pathological processes including cancer progression, where it can promote tumor growth, angiogenesis, and metastasis by modulating the tumor microenvironment. Additionally, it is involved in autoimmune diseases and chronic inflammatory conditions such as rheumatoid arthritis. In experimental models, CXCL1 is widely utilized as a biomarker for neutrophilic inflammation, and it is signaling pathway is considered a potential therapeutic target for mitigating excessive inflammation or disrupting pro-tumorigenic networks.
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