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Description
S-RMab® E-Cadherin Recombinant Rabbit mAb (SDT-438-5)Product Specification Host Rabbit Antigen E Cadherin Synonyms Cadherin 1, CAM 120 80, Epithelial cadherin, Uvomorulin, CD324, Uvomorulin, L CAM Immunogen Recombinant Protein Location Cell membrane Accession P12830 Clone Number SDT 438 5 Antibody Type Rabbit mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Predicted Reactivity Orangutan (95%) Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | E-Cadherin |
| Synonyms | Cadherin-1, CAM 120/80, Epithelial cadherin, Uvomorulin, CD324, Uvomorulin, L-CAM |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P12830 |
| Clone Number | SDT-438-5 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Orangutan (95%) |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC | 1:1000 | |
| ICC | 1:500 | |
| ICFCM | 1:50 |
Background
E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by sequestering β-catenin from its binding to LEF (Lymphoid enhancer factor)/TCF (T cell factor) which serves the function of transcribing genes of the proliferative Wnt signaling pathway. Despite the ongoing debate on whether the loss of E-cadherin is the cause or effect of epithelial-mesenchymal transition (EMT), E-cadherin functional loss has frequently been associated with poor prognosis and survival in patients of various cancers. The dysregulation of E-cadherin expression that leads to carcinogenesis happens mostly at the epigenetic level but there are cases of genetic alterations as well. E-cadherin expression has been linked to the cellular functions of invasiveness reduction, growth inhibition, apoptosis, cell cycle arrest and differentiation.
Shipping Notes
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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