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Description
Human CFB/Complement factor B Protein, His TagProduct Specification Species Human Synonyms C3 C5 convertase, Glycine rich beta glycoprotein (GBG), PBF2, Properdin factor B, BF, BFD Accession P00751 1 Amino Acid Sequence Protein sequence (P00751 1, Thr26 Leu764, with C His Tag)
Product Specification
| Species | Human |
| Synonyms | C3/C5 convertase, Glycine-rich beta glycoprotein (GBG), PBF2, Properdin factor B, BF, BFD |
| Accession | P00751-1 |
| Amino Acid Sequence | Protein sequence (P00751-1, Thr26-Leu764, with C-His Tag) TPWSLARPQGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWSTLKTQDQKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYTLRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDSVTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLSSLTETIEGVDAEDGHGPGEQQKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 84.7 kDa Observed MW: 96 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Complement Factor B is a pivotal zymogen in the alternative pathway of the complement system. This serine protease circulates in plasma and is essential for innate immunity. Its activation occurs when it binds to C3b, forming the C3 convertase (C3bBb) upon cleavage by Factor D. This enzyme complex amplifies the complement response by cleaving more C3, driving opsonization, inflammation, and the formation of the membrane attack complex. Factor B also plays a role in the lectin pathway. As a key regulator, its deficiency or dysfunction is linked to susceptibility to infections and autoimmune diseases like atypical hemolytic uremic syndrome.
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