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Description
Feline CD64 Mouse mAb (S-1088-34)Product Specification Host Mouse Antigen Feline CD64 Synonyms Fc gamma receptor Ia; FCGR1A Immunogen Recombinant Protein Location Cell membrane Accession M3X2Q6 Clone Number S 1088 34 Antibody Type Mouse mAb Isotype IgG1,k Application ELISA Reactivity Ct Purification Protein G Concentration 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from
Product Specification
| Host | Mouse |
| Antigen | Feline CD64 |
| Synonyms | Fc gamma receptor Ia; FCGR1A |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | M3X2Q6 |
| Clone Number | S-1088-34 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | ELISA |
| Reactivity | Ct |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Background
CD64, also known as FcγRI, is a high-affinity receptor for the Fc region of IgG antibodies and plays a crucial role in the immune response. It is primarily expressed on monocytes, macrophages, and dendritic cells, and can also be induced on neutrophils with IFN-γ and G-CSF. CD64 is involved in antibody-dependent cellular cytotoxicity (ADCC) and the clearance of immune complexes. The receptor's internalization process is a two-step mechanism: monomeric IgG binding leads to rapid internalization and recycling, while cross-linking causes retention and degradation of immune complexes within the cell. CD64's high affinity for IgG (in the nanomolar range) distinguishes it from other Fcγ receptors and is essential for initiating cellular effector responses even at low IgG concentrations. Structurally, CD64 consists of three extracellular Ig-like domains, a transmembrane region, and a cytoplasmic domain, with unique hinge angles that contribute to its high binding affinity. Recent studies have explored CD64 as a target for immunotherapeutic strategies in chronic inflammatory diseases, leveraging its role in macrophage activation and immune complex handling.
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