SKU: 69905776733

Biotin Mouse Anti-Human CD33 Antibody (S-R472)

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Description

Biotin Mouse Anti-Human CD33 Antibody (S-R472)Product Specification Host Mouse Antigen CD33 Synonyms Myeloid cell surface antigen CD33; Sialic acid binding Ig like lectin 3 (Siglec 3); gp67; SIGLEC3 Location Cell membrane Accession P20138 Clone Number S R472 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300

Product Specification


Host Mouse
Antigen CD33
Synonyms Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3 (Siglec-3); gp67; SIGLEC3
Location Cell membrane
Accession P20138
Clone Number S-R472
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein A
Concentration 0.2 mg/ml
Conjugation Biotin
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD33, also known as Siglec-3, is a 67 kDa type-I transmembrane sialic-acid-binding immunoglobulin-like lectin composed of an N-terminal V-set Ig domain that mediates glycan recognition, a membrane-proximal C2-set Ig domain, and a cytoplasmic tail harboring two immunoreceptor tyrosine-based inhibitory motifs (ITIMs); upon ligation by α2,3- or α2,6-linked sialylated glycoproteins or the complement component C1q, Src-family kinases phosphorylate these ITIMs, recruiting the SH2-domain-containing phosphatases SHP-1 and SHP-2 that dephosphorylate downstream signaling molecules, thereby suppressing calcium flux, PI3K activity, and activation of myeloid cells including monocytes, macrophages, dendritic cells, microglia, and myeloid-derived suppressor cells, while also modulating NK-cell cytotoxicity and cytokine production; CD33 is highly expressed on committed myeloid progenitors and over-expressed on >90 % of acute myeloid leukemias, making it the target of the antibody–drug conjugate gemtuzumab ozogamicin, and alternative splicing generates a shorter isoform lacking the ligand-binding V domain that can still dampen immune responses; genetically, the rs3865444(C) allele that reduces CD33 surface expression is protective against late-onset Alzheimer’s disease because lower microglial CD33 lessens inhibition of Aβ phagocytosis, implicating the receptor in neurodegeneration as well as in infection, autoimmunity, and cancer immune evasion.

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SKU: 69905776733

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Richard L. Yauman
Charlottesville, US
★★★★★ 5
True size
Got these for my son. He likes them. They look good on him, and they are true to size.
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Reviewed in the United States on July 2, 2024
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Al
Bozeman, US
★★★★★ 5
Great shirt for the price.
Material Type: Recycled Polyester, Color: Electric Blue, Size: Large
Bought this for my son. Very nice shirt for the price, it is true to size and the color is the same as the picture. Would definitely buy it again. The material is good quality. No issues whatsoever
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Reviewed in the United States on May 19, 2026
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SM
Whiting, US
★★★★★ 5
Great purchase
Material Type: Recycled Polyester, Color: Dark Navy, Size: X-Large
Purchased several shirts, all were great quality. You never know what you’ll get when you purchase sight unseen, these are worth it. Great value, style, and comfort. Color is exactly what you see online. True to size.
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Reviewed in the United States on November 25, 2025
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Jocelyn
Omaha, US
★★★★★ 4
Great quality for price
Material Type: Recycled Polyester, Color: Red Stripe, Size: XX-Large
Very impressed with the shirt quality, especially for such a low price. Sizing is accurate.
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Reviewed in the United States on May 21, 2026
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Shawn SnoMan Thompson
Bozeman, US
★★★★★ 5
For work or casual wear, this polo is a great choice.
Material Type: Recycled Polyester, Color: Port Stripe, Size: X-Large
I really like this polo. I've been wearing it once a week or every other week since November. Its very comfortable and breathable. This polo feels like it should last a while. The fit is good. I typcally wear XL and this XL fits great. I've pruchased it in both burgundy and black so far. I definitely recommend this shirt. For work or casual wear, this will look good.
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Reviewed in the United States on January 11, 2026

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