SKU: 70205243083

Phospho-p53 (Ser15) Rabbit Polyclonal Antibody

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Description

Phospho-p53 (Ser15) Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen Phospho p53 (Ser15) Synonyms Cellular tumor antigen p53; Antigen NY CO 13; Phosphoprotein p53; Tumor suppressor p53; P53; TP53 Immunogen Synthetic Peptide Location Nucleus Accession P04637 Antibody Type Polyclonal antibody Isotype IgG Application WB, ICC Reactivity Hu Purification Immunogen Affinity Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.

Product Specification


Host Rabbit
Antigen Phospho-p53 (Ser15)
Synonyms Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; P53; TP53
Immunogen Synthetic Peptide
Location Nucleus
Accession P04637
Antibody Type Polyclonal antibody
Isotype IgG
Application WB, ICC
Reactivity Hu
Purification Immunogen Affinity
Concentration 1 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
Dot Blot 1:1000
WB 1:1000-1:2000 Hu
ICC 1:500 Hu

Background

Phospho-p53 (Ser15) is a critical biomarker of p53 activation, playing a key role in cellular responses to DNA damage and stress. When cells experience DNA damage, p53 is phosphorylated at serine 15, which stabilizes the protein and enhances its transcriptional activity. This phosphorylation event triggers a cascade of downstream effects, including cell cycle arrest, DNA repair, and apoptosis, depending on the severity of the damage. In senescent cells, phospho-p53 (Ser15) is often localized in the nucleus, where it interacts with other proteins such as FOXO4 to maintain the senescent state and prevent apoptosis. This regulatory mechanism is crucial for understanding the balance between cellular senescence and apoptosis, and it has significant implications for aging, cancer, and other age-related diseases.

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Exchange/Return Notes
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SKU: 70205243083

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★★★★★ 5
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Reviewed in the United States on January 19, 2026
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JO
Bozeman, US
★★★★★ 4
Decent quality
Decent quality. True to size. Used for a school dance one time. If using on a regular basis would look for better quality item. Tie that was included was sooo small. Used a tie we already had instead.
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Reviewed in the United States on August 21, 2025
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Houston, US
★★★★★ 5
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Reviewed in the United States on February 20, 2026
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Amazon Customer
Bozeman, US
★★★★★ 5
Great value and quality, runs slightly small.
This is a great deal and fit perfectly! My kid is more of a size 10 but I ordered size 12. It's only slightly big in the waist but the pants have elastic adjusters so we were able to make it work. It's great quality! We ordered yellow for a school play but I plan to order other colors because my kid feels like a million bucks in his new suit.
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Sjc2110
Waukegan, US
★★★★★ 5
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