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Description
Biotin Mouse Anti-Human CD196 Antibody (S-R645)Product Specification Host Mouse Antigen CD196 Synonyms C C chemokine receptor type 6; C C CKR 6; CC CKR 6; CCR 6; Chemokine receptor like 3 (CKR L3); DRY6; G protein coupled receptor 29; GPR CY4 (GPRCY4); LARC receptor; CKRL3; CMKBR6; GPR29; STRL22; CCR6 Location Cell membrane Accession P51684 Clone Number S R645 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human PBMC Purification Protein G Concentration 0. 2
Product Specification
| Host | Mouse |
| Antigen | CD196 |
| Synonyms | C-C chemokine receptor type 6; C-C CKR-6; CC-CKR-6; CCR-6; Chemokine receptor-like 3 (CKR-L3); DRY6; G-protein coupled receptor 29; GPR-CY4 (GPRCY4); LARC receptor; CKRL3; CMKBR6; GPR29; STRL22; CCR6 |
| Location | Cell membrane |
| Accession | P51684 |
| Clone Number | S-R645 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD196, also known as CCR6 (C-C chemokine receptor type 6), is a G protein-coupled receptor primarily expressed on specific subsets of immune cells including memory T cells (particularly Th17 and regulatory T cells), immature dendritic cells, and B cells, where it serves as the exclusive receptor for the chemokine CCL20 (also called MIP-3α). This signaling axis plays a pivotal role in directing the migration of these leukocytes to inflammatory sites and secondary lymphoid organs, especially those rich in CCL20 such as the skin, lung, and mucosal tissues of the gut, thereby facilitating critical immune surveillance and the organization of adaptive immune responses. Beyond its physiological function in homeostasis and inflammation, CD196 is significantly implicated in various pathological conditions, acting as a key marker for Th17-mediated autoimmune diseases like rheumatoid arthritis, psoriasis, and multiple sclerosis, while also being exploited by certain cancers and HIV strains for cell entry or metastatic spread, making it a promising therapeutic target for modulating immune trafficking in chronic inflammatory disorders and oncology.
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Exchange/Return Notes
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