SKU: 70960147026

CD117/c-Kit Fc Chimera Protein, Mouse

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Description

CD117/c-Kit Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD117 antigen; CD117; ckit; c kit; EC 2. 7. 10; EC 2. 7. 10. 1; KIT; PBT; piebald trait; Proto oncogene c Kit; proto oncogene tyrosine protein kinase Kit; SCF R; SCFR; SCFRmast stem cell growth factor receptor; soluble KIT variant 1; Tyrosine protein kinase Kit; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein Accession P05532

Product Specification


Species Mouse
Synonyms CD117 antigen; CD117; ckit; c-kit; EC 2.7.10; EC 2.7.10.1; KIT; PBT; piebald trait; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCF R; SCFR; SCFRmast/stem cell growth factor receptor; soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Accession P05532-2
Amino Acid Sequence Ser25-Pro523, with C-terminal His
Expression System HEK293
Molecular Weight 95-120kDa (Reducing)
Purity >95% by SDS-PAGE & >95% by SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized Powder
Storage Buffer PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference


1.Kimura, Y. et al. (2011) PLoS ONE 6:e26918. 2.Tallini, Y.N. et al. (2009) Proc. Natl. Acad. Sci. USA 106:1808. 3.Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039. 4.Sun, L. et al. (2004) J. Clin. Invest. 113:1364.

Background

Stem Cell Factor Receptor (SCF R), also known as c-Kit and CD117, is a widely expressed 145 kDa receptor tyrosine kinase. It is the cellular homolog of the feline sarcoma virus protein, v-Kit. Binding of SCF R to SCF, also known as Steel Factor and Kit Ligand, promotes the survival, differentiation, and mobilization of progenitor cells in multiple lineages. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

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SKU: 70960147026

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4.7 ★★★★★
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Jack
Cuba, US
★★★★★ 5
Excellent Performance and Very Easy to Change Filter
Style: Medium Room Air Purifier
Very happy with this air purifier! It works really well and you can actually feel the air getting cleaner after running it for a while. It’s quiet, simple to use, and perfect for a medium-sized room. What I especially love is how easy it is to replace the filter. No complicated steps — just open, swap, and done in minutes. Super convenient and stress-free. For the price, the quality is surprisingly good. Definitely worth it, and I would buy again.
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Reviewed in the United States on March 1, 2026
N
Verified Purchase
Nobu
Port Orchard, US
★★★★★ 5
great solid product for the price, easy to use
Style: Medium Room Air Purifier
Bought for a family member to put in his room & it’s been super easy to set up and use. Helps noticeably freshen up the room and keep it smelling better too
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Reviewed in the United States on April 30, 2026
K
Verified Purchase
Kaleigh A
West Palm Beach, US
★★★★★ 3
Works as intended, but is badly designed
Style: Medium Room Air Purifier
This air purifier is great so far. I've only had it set up for about a day, but it seems to me that the air is cleaner so far. I got it for my office, mostly to make sure that there's less dust in the air because my allergies have been going crazy recently. The downside of this product is that the manual is just completely wrong. Both the manual + the box say to turn the bottom lid counterclockwise to open. However, I tried that and literally could not open it for the life of me. When I looked closer, I saw that there were pins holding the lid in place, and that the only place they could move was to the right - which meant turning the lid clockwise, not counter-clockwise. That wasted 15 minutes of my time trying to figure out, because clockwise didn't work either until I wiggled it. Likely the plastic surrounding the air filter was caught in the lid. Like another reviewer mentioned, the bottom lid where the filter goes doesn't really stay on tight, which is annoying. It took me a few tries to be able to put it down without the lid coming loose and the filter falling out. It's light in weight but very loud, at least when it comes to being on high (full blast). Medium is tolerable, low is preferable for whenever I'm meeting with a client. Sometimes I even turn it all the way off. It was maybe worth the price? We'll see if it helps my allergies.
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Reviewed in the United States on January 21, 2026
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Richard G
Los Angeles, US
★★★★★ 5
Very strong magnets on both sides.
Size: 12inch
You will want several. I use mine attached to the side of my large metal toolbox to make my frequently used tools easily accessible. But once connected to a large metal surface, it is very difficult to reposition which is a good thing. One surprise though, narrow shafted screws drivers don’t attach very strongly unlike other heavier tools with larger steel mounting areas for attachment. I am purchasing more for other areas in my workshop.
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Reviewed in the United States on April 21, 2026
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Amazon Customer
Bozeman, US
★★★★★ 5
good magnets
Size: 12inch
very strong magnets. they work well
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Reviewed in the United States on May 9, 2026

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