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Description
IGFBP-1 Protein, HumanProduct Specification Species Human Synonyms Insulin like growth factor binding protein 1, IBP 1, IGF binding protein 1, IGFBP 1, Placental protein 12 (PP12) Accession P08833 Amino Acid Sequence Ala26Asn259, with C terminal His tag Expression System HEK293 Molecular Weight 35 38 kDa (Reducing) Purity >95% by Bis Tris PAGE and HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4
Product Specification
| Species | Human |
| Synonyms | Insulin-like growth factor-binding protein 1, IBP-1, IGF-binding protein 1, IGFBP-1, Placental protein 12 (PP12) |
| Accession | P08833 |
| Amino Acid Sequence | Ala26Asn259, with C-terminal His tag |
| Expression System | HEK293 |
| Molecular Weight | 35-38 kDa (Reducing) |
| Purity | >95% by Bis-Tris PAGE and HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Trends Endocrinol Metab. 2009 May;20(4):153-62. |
Background
IGFBP-1 is a secreted protein encoded by the IGFBP1 gene located on chromosome 7 in humans. It is a member of the insulin-like growth factor binding protein family, which consists of six high-affinity binding proteins (IGFBP-1 to -6).
Human IGFBP-1 has evolved from being viewed as a passive IGF carrier to being recognized as a dynamic, multifunctional protein with significant IGF-independent biological activities. Its primary research utility lies in its role as a sensitive biomarker for hepatic insulin sensitivity and pregnancy-related conditions. Industrially, it is harnessed for diagnostic immunoassays and explored as a novel therapeutic target. Future research is likely to further dissect its tissue-specific roles and translational potential in metabolic, bone, and neoplastic diseases.
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