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Description
Osteocalcin/OST Recombinant Rabbit mAb (SDT-253-35)Product Specification Host Rabbit Antigen Osteocalcin OST Synonyms OC, Bone Gla protein (BGP) Immunogen Synthetic Peptide Accession P02818 Clone Number SDT 253 35 Antibody Type Recombinant mAb Application CLIA, Sandwich ELISA Reactivity Hu Cross Reactivity Recognize total Osteocalcin Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300
Product Specification
| Host | Rabbit |
| Antigen | Osteocalcin/OST |
| Synonyms | OC, Bone Gla protein (BGP) |
| Immunogen | Synthetic Peptide |
| Accession | P02818 |
| Clone Number | SDT-253-35 |
| Antibody Type | Recombinant mAb |
| Application | CLIA, Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | Recognize total Osteocalcin |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| Sandwich ELISA | N/A |
Background
Osteocalcin (OC), also known as bone gla protein (BGP), is a 49 amino acid vitamin K-dependent calcium binding protein with a molecular weight of 5.9 kDa. Carboxylated OC (Gla-OC), which is capable of binding calcium, is the active form of the protein and decarboxylated OC represents the inactive form. Gla-OC has three γ-carboxylated glutamic acid residues (Gla) at positions 17, 21, and 24 that are known to mediate strong binding to hydroxyapatite. OC synthesis is dependent on both vitamins D and K. Vitamin D directly induces OC synthesis and vitamin K stimulates the gamma-carboxylation of glutamic acid residues. During osteoclastic resorption, binding of undercarboxylated osteocalcin (Glu-OC) to bone decreases, resulting in an increase in Glu-OC level in blood and urine. P. D. Delmas and colleagues have shown that undercarboxylated OC is significantly increased in elderly women, suggesting an age-dependent impairment of OC γ-carboxylation. The presence of undercarboxylated OC in serum has also been associated with changes to the bone matrix and increased fragility.
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