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Description
Invivo Anti-Mouse CD20 Recombinant mAbProduct Specification Host Mouse Antigen CD20 Synonyms B lymphocyte antigen CD20; B cell differentiation antigen Ly 44; Lymphocyte antigen 44; Membrane spanning 4 domains subfamily A member 1; Ly 44; Ms4a2; Ms4a1 Location Cell membrane Accession P19437 Clone Number S 3682 Antibody Type Mouse mAb Isotype Mouse IgG2c, Application FCM, in vivo B cell depletion Purification Protein G Concentration 5 mg ml Purity >95% (Determined by SDS PAGE) Endotoxin
Product Specification
| Host | Mouse |
| Antigen | CD20 |
| Synonyms | B-lymphocyte antigen CD20; B-cell differentiation antigen Ly-44; Lymphocyte antigen 44; Membrane-spanning 4-domains subfamily A member 1; Ly-44; Ms4a2; Ms4a1 |
| Location | Cell membrane |
| Accession | P19437 |
| Clone Number | S-3682 |
| Antibody Type | Mouse mAb |
| Isotype | Mouse IgG2c, κ |
| Application | FCM, in vivo B cell depletion |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
CD20 is a 33-37 kDa non-glycosylated phosphoprotein expressed on the surface of B cells from the pre-B cell stage through maturity, but absent on plasma cells. It belongs to the MS4A protein family and has four transmembrane domains, one intracellular domain, and two extracellular loops. CD20 is believed to facilitate calcium influx, which is essential for B cell activation and proliferation. Although its exact biological function is not fully elucidated, studies suggest it plays a role in B cell receptor signaling and may act as a calcium channel. CD20 is a key therapeutic target for B cell malignancies and autoimmune diseases, as it is expressed on various B cell cancers and its targeting can induce cell death through mechanisms like complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity.
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