Pay in installments of $37.50 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 18 - Aug 23
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
APC Mouse Anti-Human CD16 Antibody (S-R440)Product Specification Host Mouse Antigen CD16 Synonyms Low affinity immunoglobulin gamma Fc region receptor III A; IgG Fc receptor III A; CD16 II; CD16a antigen; Fc gamma RIII alpha (Fc gamma RIII; Fc gamma RIIIa; FcRIII; FcRIIIa; FcgammaRIIIA); FcR 10; IgG Fc receptor III 2; CD16a; FCG3; FCGR3; IGFR3; FCGR3A Location Secreted, Cell membrane Accession P08637 Clone Number S R440 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu
Product Specification
| Host | Mouse |
| Antigen | CD16 |
| Synonyms | Low affinity immunoglobulin gamma Fc region receptor III-A; IgG Fc receptor III-A; CD16-II; CD16a antigen; Fc-gamma RIII-alpha (Fc-gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcgammaRIIIA); FcR-10; IgG Fc receptor III-2; CD16a; FCG3; FCGR3; IGFR3; FCGR3A |
| Location | Secreted, Cell membrane |
| Accession | P08637 |
| Clone Number | S-R440 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 0.2mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD16, also known as FcγRIII, is a type of glycoprotein belonging to the immunoglobulin superfamily. It is divided into two subtypes: CD16a (FcγRIIIa) and CD16b (FcγRIIIb). CD16a is a transmembrane protein mainly expressed on natural killer (NK) cells, monocytes, and some T cell subsets, while CD16b is a GPI-anchored protein primarily found on neutrophils. CD16a can mediate antibody-dependent cell cytotoxicity (ADCC) by binding to the Fc region of IgG antibodies, which is crucial for the immune system to eliminate virus-infected cells and cancer cells. Additionally, CD16a is one of the core markers for defining NK cells and can promote their proliferation and secretion of cytotoxic cytokines. In cancer immunotherapy, CD16a is an important target protein, and some monoclonal antibody drugs are designed to enhance its binding ability to boost immune responses.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy