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Description
KDM4A Recombinant Rabbit mAb (S-957-138)Product Specification Host Rabbit Antigen KDM4A Synonyms Lysine specific demethylase 4A; JmjC domain containing histone demethylation protein 3A; Jumonji domain containing protein 2A; [histone H3] trimethyl L lysine(36) demethylase 4A; [histone H3] trimethyl L lysine(9) demethylase 4A; JHDM3A; JMJD2; JMJD2A; KIAA0677 Immunogen Synthetic Peptide Location Nucleus Accession O75164 Clone Number S 957 138 Antibody Type Recombinant mAb Isotype IgG
Product Specification
| Host | Rabbit |
| Antigen | KDM4A |
| Synonyms | Lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A; [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; JHDM3A; JMJD2; JMJD2A; KIAA0677 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | O75164 |
| Clone Number | S-957-138 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, LNCaP, MCF7, HeLa, SH-SY5Y, NIH/3T3, PC-12 |
| Predicted Reactivity | Or |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:4000 | Hu, Ms, Rt |
| IHC-P | 1:100 | Hu, Ms, Rt |
| ICC | 1:1000-1:2000 | Hu, Ms |
Background
KDM4A (also known as JMJD2A, JHDM3A) is a 125 kDa Fe(II)- and α-ketoglutarate-dependent nuclear histone demethylase that specifically removes di- and tri-methyl marks from H3K9 and H3K36, thereby acting as a transcriptional repressor or activator, depending on context, to modulate chromatin structure and gene expression; it cycles in abundance through G1/S to G2/M via ubiquitin-proteasome control, localizes to nucleoli where it associates with rDNA and RNA polymerase I, participates in replication timing and site-specific DNA re-replication, and also localizes to centrosomes where its enzymatic activity safeguards centrosome integrity and mitotic fidelity, while its dysregulation is linked to diverse cancers and other diseases, making it a therapeutic and diagnostic target.
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