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Description
P-Selectin/CD62P Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms GMP 140, LECAM3, PADGEM Accession Q01102 Amino Acid Sequence Trp42 Ala709, with C terminal Fc Expression System HEK293 Molecular Weight 115 140kDa (Reducing) Purity 95% by SDS PAGE & SEC HPLC Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Mouse |
| Synonyms | GMP-140, LECAM3, PADGEM |
| Accession | Q01102 |
| Amino Acid Sequence | Trp42-Ala709, with C-terminal Fc |
| Expression System | HEK293 |
| Molecular Weight | 115-140kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Weller A, Isenmann S, Vestweber D. Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha. J Biol Chem. 1992 Jul 25;267(21):15176-83. |
Background
Mouse P-Selectin, also known as GMP-140, LECAM-3, PADGEM, or CD62P, is a member of the Selectin family of cell surface glycoproteins. It is expressed by activated platelets and endothelial cells. The cDNA for Mouse P-Selectin encodes a 768 amino acid (aa) type I transmembrane protein. This protein comprises a 41 aa signal peptide, a 668 aa extracellular domain, a transmembrane domain, and a short (35 aa) cytoplasmic domain.
The extracellular domain of Mouse P-Selectin features an NH2-terminal C-type lectin domain and an EGF-like domain, succeeded by a series of complement factor A repeat homology domains. There is approximately 73% sequence homology between the extracellular domains of human and mouse P-Selectin.
P-Selectin is crucial for the adhesion of leukocytes and neutrophils to the endothelium. In conjunction with L-Selectin, it mediates the initial interaction between circulating leukocytes and endothelial cells, resulting in a characteristic 'rolling' phenomenon of leukocytes along the endothelium. Following this initial interaction, a stronger bond forms, involving E-Selectin, and subsequently ICAM-1 and VCAM-1. This sequence of events ultimately facilitates the extravasation of white blood cells through the blood vessel wall and into the surrounding tissue matrix.
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