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Description
CD70 Recombinant Rabbit mAb (S-1725-277)Product Specification Host Rabbit Antigen CD70 Synonyms CD70 antigen; CD27 ligand (CD27 L); Tumor necrosis factor ligand superfamily member 7Imported; CD27L; CD27LG; TNFSF7 Immunogen Recombinant Protein Location Cell membrane Accession P32970 Clone Number S 1725 277 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample U266B1, SK OV 3 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | CD70 |
| Synonyms | CD70 antigen; CD27 ligand (CD27-L); Tumor necrosis factor ligand superfamily member 7Imported; CD27L; CD27LG; TNFSF7 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P32970 |
| Clone Number | S-1725-277 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | U266B1, SK-OV-3 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu |
| ICC | 1:100 | Hu |
Background
CD70, also known as CD27 ligand, is a type Ⅱ transmembrane protein that plays a crucial role in the immune system. It is primarily expressed on antigen - presenting cells (APCs) such as dendritic cells, macrophages, and B cells, as well as on activated T cells. CD70 interacts with its receptor CD27, which is mainly found on T cells, B cells, and natural killer (NK) cells. This interaction provides important co - stimulatory signals that promote T cell activation, proliferation, and differentiation, and also enhances B cell and NK cell functions. Additionally, CD70 is involved in the regulation of immune responses, including the maintenance of immune homeostasis and the induction of immune - mediated tumor cell killing. Abnormal expression of CD70 has been associated with various diseases, such as autoimmune disorders and certain types of cancers. Therefore, CD70 is considered a promising target for the development of immunotherapies.
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Exchange/Return Notes
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