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Description
CDK9 Recombinant Rabbit mAb (S-2661-10)Product Specification Host Rabbit Antigen CDK9 Synonyms Cyclin dependent kinase 9; Cell division protein kinase 9; Cdk9 Immunogen Recombinant Protein Location Cytoplasm, Nucleus Accession Q99J95 Clone Number S 2661 10 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HT 29, HeLa, HL 60, HEK 293, NIH 3T3, RAW264. 7, mouse testis, mouse liver, PC 12, C6, rat testis, rat liver Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | CDK9 |
| Synonyms | Cyclin-dependent kinase 9; Cell division protein kinase 9; Cdk9 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Nucleus |
| Accession | Q99J95 |
| Clone Number | S-2661-10 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HT-29, HeLa, HL-60, HEK-293, NIH/3T3, RAW264.7, mouse testis, mouse liver, PC-12, C6, rat testis, rat liver |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
CDK9 (cyclin-dependent kinase 9) is the catalytic subunit of the positive transcription elongation factor b (P-TEFb), which phosphorylates the RNA polymerase II C-terminal domain and negative elongation factors to promote productive elongation of RNA synthesis; in its activated form CDK9 is complexed with cyclin T or cyclin K and is essential for expression of most RNA polymerase II-dependent genes, and because it controls transcriptional elongation of key regulators of cell proliferation and survival—especially MCL-1, MYC and cyclin D1—CDK9 is an attractive therapeutic target in cancer, inflammation and viral infections, with several ATP-competitive inhibitors such as flavopiridol, dinaciclib and alvocidib already in clinical trials.
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