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Description
LAIR1/CD305 mFc Chimera Protein, HumanProduct Specification Species Human Synonyms Immunoglobulin Heavy Chain Variable RegionHLAIR1LAIR1Leukocyte Associated Immunoglobulin Like Receptor 1CD305 AntigenhLAIR1CD305Leukocyte Associated Ig Like Receptor 1 Accession Q6GTX8 1 Amino Acid Sequence Gln22 His163, with mIgG Fc Expression System HEK293 Molecular Weight 50 65kDa (Reducing) Purity 95% by SDS PAGE & SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Physical Appearance Lyophilized
Product Specification
| Species | Human |
| Synonyms | Immunoglobulin Heavy Chain Variable Region，HLAIR1，LAIR1，Leukocyte Associated Immunoglobulin Like Receptor 1，CD305 Antigen，hLAIR1，CD305，Leukocyte-Associated Ig-Like Receptor 1 |
| Accession | Q6GTX8-1 |
| Amino Acid Sequence | Gln22 - His163, with mIgG Fc |
| Expression System | HEK293 |
| Molecular Weight | 50-65kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Meyaard, L. (2008) J. Leukoc. Biol. 83:799. Meyaard, L. et al. (1997) Immunity 7:283. Lebbink, R.J. et al. (2004) J. Immunol. 172:5535. Ouyang, W. et al. (2003) Biochem. Biophys. Res. Commun. 310:1236. |
Background
LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily. Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is a type I glycoprotein of 287 amino acids containing a single extracellular Ig-like domain followed by a stalk region connected to the single transmembrane domain and 2 cytoplasmic immunoreceptor tyrosine-based inhibitory motifs that relay the inhibitory signal. LAIR-1 is expressed on almost all immune cells, including NK cells, T cells, B cells and mono-cytes, monocyte-derived dendritic cells, eosinophils, and basophils and mast cells. LAIR-1 binds both transmembrane and extracellular matrix collagens. The mLAIR-1 gene maps to the proximal end of mouse chromosome 7 in a region syntenic with human chromosome 19q13.4 where the LRC is located. LAIR-1 are involved in controlling the balance of the immune system to prevent improper activation or overactivation, which may result in tissue damage or autoimmune diseases. LAIR1 has been shown to inhibit T and NK cell activation mediated by several activating receptors. Furthermore, it has been shown that LAIR1 can deliver an inhibiting signal on intracellular free calcium concentration and immunoglobulin (Ig) production induced by the engagement of B cell antigen receptors (BCR).
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